Co-occurrence of early diabetes-related complications in adolescents and young adults with type 1 diabetes: an observational cohort study.

The Lancet Child & Adolescent Health
Katherine A SauderSEARCH for Diabetes in Youth Study Group

Abstract

One in three adolescents and young adults with type 1 diabetes have at least one early diabetes-related complication or comorbidity. We aimed to examine the prevalence and pattern of co-occurring complications in this population, as well as the related risk factors. This observational cohort study includes data from individuals diagnosed with type 1 diabetes before age 20 years who participated in the SEARCH for Diabetes in Youth Study across five sites in the USA. We assessed sociodemographic and metabolic risk factors at baseline and at follow-up, and diabetes complications at follow-up. A frequency analysis was done to examine the difference in observed versus expected prevalence (calculated using a contingency table assuming independence across cells) of co-occurring complications or comorbidities. A cluster analysis was done to identify unique clusters of participants based on demographic characteristics and metabolic risk factors. 1327 participants who completed the follow-up visit were included in the frequency analysis. The mean age was 10·1 (SD 3·9) years at the time of type 1 diabetes diagnosis and 18·0 (4·1) years at follow-up. At a mean diabetes duration of 7·8 [SD 1·9] years, co-occurrence of any two or more compli...Continue Reading

Citations

Jul 5, 2019·Pediatric Diabetes·Maria C Ibanez-BruronUNKNOWN Diabetic Eye Disease in Childhood Study (DECS) group
Sep 10, 2019·Diabetic Medicine : a Journal of the British Diabetic Association·O KordonouriT Danne
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