Co-occurrence of papillary thyroid carcinoma and primary lymphoma of the thyroid in a patient with long-standing Hashimoto's thyroiditis

Thyroid : Official Journal of the American Thyroid Association
Vicky ChengChristian Nasr

Abstract

Papillary thyroid carcinoma (PTC) is the most common type of thyroid cancer, whereas mucosa-associated lymphoid tissue (MALT) lymphoma of the thyroid gland is uncommon. Simultaneous occurrence of both disease entities is very rare. A 59-year-old man with known hypothyroidism from Hashimoto's thyroiditis (HT) was seen for thyroid nodules. A thyroid ultrasound revealed a heterogeneous thyroid gland with two hypoechoic nodules, one in the right aspect of the isthmus measuring 2.0 cm×3.2 cm×1.7 cm and another one in the left lobe measuring 1.4 cm×1.3 cm×1.2 cm. A fine-needle aspiration (FNA) of the right-sided nodule revealed atypical epithelial cells and atypical lymphoid cells in a background of lymphocytic thyroiditis; FNA of the left-sided nodule showed findings of PTC. A total thyroidectomy was performed. Lymph node dissection was not performed. Pathology showed extranodal marginal zone B-cell lymphoma of MALT type with extreme plasmacytic differentiation in the right nodule and PTC in the left nodule (pT1b Nx Mx). Postoperatively, he underwent radioactive iodine ablation treatment. There was only minimal neck uptake on the post-treatment scan. Further work-up did not show any evidence of extrathyroidal lymphoma. Seven years a...Continue Reading

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Citations

May 27, 2014·Endocrinología y nutrición : órgano de la Sociedad Española de Endocrinología y Nutrición·José Manuel Gómez Sáez
Mar 5, 2015·Journal of Endocrinological Investigation·L YangY Mu
Aug 30, 2016·Asian Pacific Journal of Tropical Medicine·Saul Levy-BlitchteinJuana Del Valle Mendoza
Jul 5, 2016·Der Pathologe·P MeisterM-L Hansmann
Feb 8, 2018·Archives of Endocrinology and Metabolism·Maria TrovatoAlfredo Campennì
Oct 5, 2019·American Journal of Clinical Pathology·Antonio TravaglinoMassimo Mascolo
Nov 21, 2017·Turkish Journal of Medical Sciences·Hasan BostancıMurat Akın
Dec 30, 2016·Chinese Medical Sciences Journal = Chung-kuo I Hsüeh K'o Hsüeh Tsa Chih·Qiong WuBo Zhang
Aug 19, 2020·European Journal of Cancer Prevention : the Official Journal of the European Cancer Prevention Organisation (ECP)·Yicheng WangXiequn Xu

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Methods Mentioned

BETA
flow cytometry
biopsy

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