Co-occurrence of point mutations in the voltage-gated sodium channel of pyrethroid-resistant Aedes aegypti populations in Myanmar

PLoS Neglected Tropical Diseases
Hitoshi KawadaNoboru Minakawa

Abstract

Single amino acid substitutions in the voltage-gated sodium channel associated with pyrethroid resistance constitute one of the main causative factors of knockdown resistance in insects. The kdr gene has been observed in several mosquito species; however, point mutations in the para gene of Aedes aegypti populations in Myanmar have not been fully characterized. The aim of the present study was to determine the types and frequencies of mutations in the para gene of Aedes aegypti collected from used tires in Yangon City, Myanmar. We determined high pyrethroid resistance in Aedes aegypti larvae at all collection sites in Yangon City, by using a simplified knockdown bioassay. We showed that V1016G and S989P mutations were widely distributed, with high frequencies (84.4% and 78.8%, respectively). By contrast, we were unable to detect I1011M (or I1011V) or L1014F mutations. F1534C mutations were also widely distributed, but with a lower frequency than the V1016G mutation (21.2%). High percentage of co-occurrence of the homozygous V1016G/S989P mutations was detected (65.7%). Additionally, co-occurrence of homozygous V1016G/F1534C mutations (2.9%) and homozygous V1016G/F1534C/S989P mutations (0.98%) were detected in the present study. ...Continue Reading

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Citations

Oct 16, 2016·Pesticide Biochemistry and Physiology·Letícia B SmithJeffrey G Scott
Oct 1, 2015·BioMed Research International·Xiaohong WangJun Li
Jun 6, 2015·Pesticide Biochemistry and Physiology·René FeyereisenThomas Van Leeuwen
Nov 21, 2015·PLoS Neglected Tropical Diseases·Isabelle DusfourClare Strode
Mar 6, 2018·Asia-Pacific Journal of Public Health·Sébastien BoyerJeffrey Hii
Jun 25, 2019·PloS One·Tri Baskoro Tunggul Satoto Kuswati
Apr 18, 2020·PLoS Neglected Tropical Diseases·Yinjun FanJeffrey G Scott
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Related Concepts

AB914687
AB914688
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Aedes
Metazoa
Insecticide Resistance
Insecticides
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Pyrethroids

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