PMID: 8948428Jun 15, 1995Paper

Co-ordinate decrease in the expression of the mitochondrial genome and nuclear genes for mitochondrial proteins in the lactation-induced mitochondrial hypotrophy of rat brown fat

The Biochemical Journal
I MartinF Villarroya

Abstract

The relative abundance of the mitochondrial-encoded mRNAs for cytochrome c oxidase subunit II and NADH dehydrogenase subunit I was lower in brown adipose tissue (BAT) from lactating rats than in virgin controls. This decrease was in parallel with a significant decrease in mitochondrial 16 S rRNA levels and in the relative content of mitochondrial DNA in the tissue. BAT from lactating rats showed lowered mRNA expression of the nuclear-encoded genes for the mitochondrial uncoupling protein, subunit IV of cytochrome c oxidase and the adenine nucleotide translocase isoforms ANT1 and ANT2, whereas mRNA levels for the ATP synthase beta-subunit were unchanged. However, the relative content of this last protein was lower in BAT mitochondria from lactating rats than in virgin controls. It is concluded that lactation-induced mitochondrial hypotrophy in BAT is associated with a co-ordinate decrease in the expression of the mitochondrial genome and nuclear genes for mitochondrial proteins. This decrease is caused by regulatory events acting at different levels, including pre- and post-transcriptional regulation. BAT appears to be a useful model with which to investigate the molecular mechanisms involved in the co-ordination of the expressi...Continue Reading

Citations

Nov 6, 2007·Cellular Physiology and Biochemistry : International Journal of Experimental Cellular Physiology, Biochemistry, and Pharmacology·Sergio Rodriguez-CuencaPilar Roca
Mar 31, 2012·Journal of Molecular Endocrinology·Carmelo QuartaUberto Pagotto
Apr 10, 2002·The Journal of Biological Chemistry·M Carmen CarmonaMarta Giralt
Jan 13, 2004·Physiological Reviews·Barbara Cannon, Jan Nedergaard
Apr 8, 1998·The American Journal of Physiology·X H NingM A Portman
Aug 13, 1999·The American Journal of Physiology·I HardewigH O Pörtner
Nov 26, 2011·The Journal of Experimental Biology·Elzbieta KrólJohn R Speakman

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