PMID: 8949432Sep 1, 1996Paper

Co-ordinate induction of collagen type I and biglycan expression in keloids

The British Journal of Dermatology
N HunzelmannT Krieg

Abstract

Proteoglycans are macromolecules displaying structural roles as well as regulatory functions in the maintenance of the extracellular matrix. Biglycan/PG-I and decorin/PG-II are two small proteoglycans that are structurally related but differ considerably in their localization in vivo and behaviour in vitro. Decorin and, to a minor extent, biglycan, can be located at the surface of type I collagen fibrils and have been shown to influence collagen fibrillogenesis. However, the physiological role of biglycan in the dermis is not known. Biopsies obtained from keloids were bisected and processed for total RNA extraction and immunohistochemistry. Northern blot analysis of total RNA obtained from keloids with high growth tendency in vivo showed a marked induction of biglycan and collagen alpha 1(I)mRNA expression in comparison with total RNA obtained from normal skin or keloids with little growth tendency. In contrast, decorin mRNA expression remained largely unaltered. Studying these biopsies by immunohistochemistry, decorin expression in the dermis was unaltered comparing normal and keloid tissue, whereas a markedly increased staining for biglycan was observed in the keloid tissue, which was most pronounced in the nodular formations...Continue Reading

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Citations

Oct 8, 2009·Journal of Cell Communication and Signaling·Rosetta MerlineLiliana Schaefer
Jan 8, 1998·Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research·A M HeegaardM F Young
Jun 10, 2005·Arthroscopy : the Journal of Arthroscopic & Related Surgery : Official Publication of the Arthroscopy Association of North America and the International Arthroscopy Association·Ian K Y LoCyril B Frank
Sep 22, 2006·Connective Tissue Research·Osamu Okamoto, Sakuhei Fujiwara
Mar 10, 2009·Burns : Journal of the International Society for Burn Injuries·Janakiraman MeenakshiMary Babu
Aug 16, 2011·Journal of the European Academy of Dermatology and Venereology : JEADV·G P Sidgwick, A Bayat
Mar 19, 2016·Advances in Wound Care·Lauren E TracyE J Caterson
Mar 5, 2002·The Journal of Investigative Dermatology·Greg SzulgitHumphrey Gardner
Sep 13, 2016·Experimental and Molecular Pathology·Emily FullerJames Melrose
Jul 24, 2012·The Journal of Histochemistry and Cytochemistry : Official Journal of the Histochemistry Society·Madalina V NastaseLiliana Schaefer
Oct 8, 1999·Plastic and Reconstructive Surgery·F B NiessenM Kon
Jan 10, 1998·The Journal of Pathology·J A McGrath, R A Eady
Mar 14, 2000·Cell Death and Differentiation·C C ChipevM Simon
Dec 6, 2005·Plastic and Reconstructive Surgery·Andrew Burd, Lin Huang
Jan 13, 2006·Plastic and Reconstructive Surgery·Ali Al-AttarSteven P Davison

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