Co-ordinated expression of lymphoid and myeloid specific transcription factors during B-1b cell differentiation into mononuclear phagocytes in vitro.

Immunology
Ana Flavia PopiMario Mariano

Abstract

We previously demonstrated that B-1b cells can undergo differentiation to acquire a mononuclear phagocyte phenotype upon attachment to substrate in vitro. Here we followed the expression of surface markers and transcription factors during this differentiation. B-1b cells spontaneously express both myeloid and lymphoid restricted transcription factors. When induced to differentiate into a phagocyte, the lymphoid genes E box protein (E2A), early B-cell factor (EBF), paired box 5 (Pax5) are down-modulated, while expression of genes related to myeloid commitment is sustained. Furthermore, B-1b cell-derived phagocytes (B-1CDPs) decrease immunoglobulin M (IgM) expression but retain the expression of the heavy chain variable gene VH11 or VH12, an immunoglobulin gene rearrangement predominantly expressed by B-1 cells. The maintenance of lymphoid characteristics in B-1CDPs characterizes a unique type of phagocyte, not related to monocyte-derived macrophages.

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Citations

Apr 7, 2010·Proceedings of the National Academy of Sciences of the United States of America·Roselynn Rodriguez-ManzanetVijay K Kuchroo
Mar 11, 2010·Journal of Atherosclerosis and Thrombosis·Waldir G M RelvasFrancisco A H Fonseca
Feb 22, 2014·Immunobiology·M C AzevedoM Mariano
Feb 23, 2013·Evidence-based Complementary and Alternative Medicine : ECAM·Leoni Villano BonaminMario Mariano
Jun 5, 2012·Pathology, Research and Practice·Caterina DefendentiPiercarlo Sarzi-Puttini
Aug 23, 2011·Immunobiology·Livia Souza PuglieseJosé Daniel Lopes
Nov 18, 2015·Molecular Immunology·Lv-Yun ZhuJian-Zhong Shao
Apr 25, 2009·Immunology Letters·Luiz Antonio De-GennaroMario Mariano
Mar 27, 2009·Immunobiology·A F PopiM Mariano
Jul 8, 2015·Annals of the New York Academy of Sciences·Ana Flavia Popi
Apr 26, 2012·European Journal of Immunology·Jixin GaoYufeng Liu
Feb 18, 2015·European Journal of Immunology·Anuska M Alvares-SaraivaMario Mariano
May 6, 2016·Frontiers in Immunology·Ana F PopiMario Mariano
Sep 8, 2012·Immunobiology·Maria Fernanda Lucatelli LaurindoAna Flavia Popi
Sep 24, 2014·Immunobiology·Marilia Campos Tavares NovoAna Flavia Popi
Sep 2, 2009·Anais Da Academia Brasileira De Ciências·José Daniel Lopes, Mario Mariano
Jun 8, 2017·World Journal of Biological Chemistry·Angelica F ArcanjoCelio Geraldo Freire-de-Lima
Aug 8, 2017·The Journal of Parasitology·Wagner Francisco Kennerly Marcondes GonzagaPatricia Xander
May 4, 2017·Proceedings of the National Academy of Sciences of the United States of America·Tatsiana AudzevichDerek W Gilroy
Apr 4, 2019·Parasitology Research·Ronni Rômulo Novaes E BritoPatricia Xander
Dec 3, 2014·Homeopathy : the Journal of the Faculty of Homeopathy·Fabiana Rodrigues de SantanaLeoni Villano Bonamin
Nov 17, 2020·Frontiers in Cellular and Infection Microbiology·Natasha Ferraz de Campos ReisPatricia Xander
Jun 15, 2021·Frontiers in Medicine·William T Nash, Mark D Okusa

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