Co-production of MCR-1 and NDM-5 in Escherichia coli isolated from a colonization case of inpatient

Infection and Drug Resistance
Siyuan FengGuo-Bao Tian

Abstract

Colistin is increasingly used as an antibiotic of last resort for treating carbapenem-resistant Enterobacteriaceae. Mobile colistin resistance gene mcr-1 has been increasingly reported in Enterobacteriaceae around the world. Of particular concern is the spread of mcr-1 into carbapenemase-producing Enterobacteriaceae, which results in highly drug-resistant strains that are potentially untreatable. Notably, such mcr-1-carrying isolates harboring carbapenemase genes have been reported in animals and patients with infection. Here, we report an Escherichia coli strain carrying co-transferable mcr-1-harboring IncX4 and blaNDM-5-harboring IncX3 plasmids, which was recovered in the context of fecal colonization.

Datasets Mentioned

BETA
NEFV00000000
GB788

Methods Mentioned

BETA
PCRs
electrophoresis

Software Mentioned

GCview
BLASTn
BLASTp

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