Co-registered Topographical, Band Excitation Nanomechanical, and Mass Spectral Imaging Using a Combined Atomic Force Microscopy/Mass Spectrometry Platform

ACS Nano
Olga S OvchinnikovaGary J Van Berkel

Abstract

The advancement of a hybrid atomic force microscopy/mass spectrometry imaging platform demonstrating the co-registered topographical, band excitation nanomechanical, and mass spectral imaging of a surface using a single instrument is reported. The mass spectrometry-based chemical imaging component of the system utilized nanothermal analysis probes for pyrolytic surface sampling followed by atmospheric pressure chemical ionization of the gas-phase species produced with subsequent mass analysis. The basic instrumental setup and operation are discussed, and the multimodal imaging capability and utility are demonstrated using a phase-separated polystyrene/poly(2-vinylpyridine) polymer blend thin film. The topography and band excitation images showed that the valley and plateau regions of the thin film surface were comprised primarily of one of the two polymers in the blend with the mass spectral chemical image used to definitively identify the polymers at the different locations. Data point pixel size for the topography (390 nm × 390 nm), band excitation (781 nm × 781 nm), and mass spectrometry (690 nm × 500 nm) images was comparable and submicrometer in all three cases, but the data voxel size for each of the three images was dram...Continue Reading

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Jul 1, 2014·Rapid Communications in Mass Spectrometry : RCM·Olga S OvchinnikovaGary J Van Berkel

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Citations

Feb 27, 2016·ACS Applied Materials & Interfaces·Alex BelianinovOlga S Ovchinnikova
Apr 19, 2016·Analytical Chemistry·Zhenpeng ZhouRichard N Zare
Sep 28, 2016·ACS Nano·Sergei V KalininStephen Jesse
Sep 28, 2017·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Martin R L PaineShane R Ellis
Oct 8, 2020·Analytical and Bioanalytical Chemistry·Olga S OvchinnikovaRoger Proksch
Nov 23, 2019·Analytical Chemistry·Tongtong WangWei Hang
Nov 25, 2020·ACS Nano·Matthias LorenzOlga S Ovchinnikova
Nov 14, 2018·ACS Nano·Alex BelianinovOlga S Ovchinnikova

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