Co-registration of glucose metabolism with positron emission tomography and vascularity with fluorescent diffuse optical tomography in mouse tumors.

EJNMMI Research
Xiao TongBertrand Tavitian

Abstract

Bimodal molecular imaging with fluorescence diffuse optical tomography (fDOT) and positron emission tomography (PET) has the capacity to provide multiple molecular information of mouse tumors. The objective of the present study is to co-register fDOT and PET molecular images of tumors in mice automatically. The coordinates of bimodal fiducial markers (FM) in regions of detection were automatically detected in planar optical images (x, y positions) in laser pattern optical surface images (z position) and in 3-D PET images. A transformation matrix was calculated from the coordinates of the FM in fDOT and in PET and applied in order to co-register images of mice bearing neuroendocrine tumors. The method yielded accurate non-supervised co-registration of fDOT and PET images. The mean fiducial registration error was smaller than the respective voxel sizes for both modalities, allowing comparison of the distribution of contrast agents from both modalities in mice. Combined imaging depicting tumor metabolism with PET-[18 F]2-deoxy-2-fluoro-d-glucose and blood pool with fDOT demonstrated partial overlap of the two signals. This automatic method for co-registration of fDOT with PET and other modalities is efficient, simple and rapid, o...Continue Reading

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Citations

Aug 29, 2012·Molecular Imaging and Biology : MIB : the Official Publication of the Academy of Molecular Imaging·Anikitos GarofalakisFrédéric Ducongé

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Methods Mentioned

BETA
fluorescence
xenografts
xenograft
transfection
imaging techniques

Software Mentioned

Brainvisa
fDOT
FM
MicroPET Manager

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