Co-release of neuropeptide Y and catecholamines upon adrenal activation in the cat

Acta Physiologica Scandinavica
J M LundbergE Theodorsson-Norheim

Abstract

The release of neuropeptide Y (NPY)-like immunoreactivity (-LI) in relation to catecholamines from the cat adrenal was studied in anaesthetized animals. Abdominal surgery increased plasma levels of NPY-LI from 65 +/- 6 to 149 +/- 26 pmol l-1. A positive veno-arterial concentration gradient over the adrenal gland was found for both NPY-LI, adrenaline (Adr) and noradrenaline (NA) during basal conditions. Asphyxia for 2 min increased the output of both NPY-LI and catecholamines from the adrenal. Electrical stimulation of the splanchnic nerve caused a marked increase in adrenal output of NPY-LI and catecholamines. The adrenal content of NPY-LI, as well as the release of NPY-LI from the adrenal, was at least 1000-fold lower on a molar basis than that of catecholamines. The concentration of NPY-LI in the adrenal vein upon splanchnic nerve stimulation was in the nM range. Reversed-phase HPLC characterization revealed that NPY-LI in the adrenal, and in the adrenal venous plasma collected during splanchnic nerve stimulation, was closely related to synthetic porcine NPY. Stimulation with bursts of 20 Hz for 1 S with 10 s intervals for 2 min caused a four-fold higher output of NPY-LI and Adr compared to a continuous stimulation with 2 Hz,...Continue Reading

References

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Citations

Feb 1, 1986·Naunyn-Schmiedeberg's Archives of Pharmacology·J M LundbergE Theodorsson-Norheim
Aug 11, 1987·Brain Research·T NakajimaK Nakamura
Oct 10, 1996·European Journal of Pharmacology·L W HunterD K Rorie
Apr 1, 1987·Neuropeptides·G Mazzocchi, G G Nussdorfer
May 1, 1992·Journal of the Autonomic Nervous System·S L StoddardT L Yaksh
Jan 1, 1989·Peptides·R K Harding, T J McDonald
May 1, 1990·Peptides·J C Jørgensen, P Sejrsen
Jan 1, 1992·Progress in Neurobiology·Y DumontR Quirion
Feb 26, 2003·European Journal of Pharmacology·Gonzalo A Carrasco, Louis D Van de Kar
Apr 5, 2001·Peptides·D Renshaw, J P Hinson
Feb 1, 2003·ASAIO Journal : a Peer-reviewed Journal of the American Society for Artificial Internal Organs·Ingegerd Odar-CederlöfCarl M Kjellstrand
Oct 1, 1990·Zentralblatt für Veterinärmedizin. Reihe A·D M Gaumann, T L Yaksh
Jan 1, 1990·Fundamental & Clinical Pharmacology·J M LundbergJ Pernow
Feb 14, 2016·Current Osteoporosis Reports·Harry Horsnell, Paul A Baldock
Feb 4, 2003·The Journal of Physiology·Emilia M SanhuezaDino A Giussani
Jun 3, 2008·The European Journal of Neuroscience·Heather L ScanlinAgnieszka Balkowiec

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