PMID: 3744595Sep 15, 1986Paper

Co-reversion of a lectin-resistant mutation and non-metastatic phenotype in murine tumor cells

International Journal of Cancer. Journal International Du Cancer
J W Dennis, S Laferté

Abstract

Three independent isolates, one obtained spontaneously and the others obtained after in vitro mutagenesis, of a WGA-resistant mutation were compared to the highly metastatic parental murine cell line MDAY-D2 for alterations in plasma membrane glycoproteins and changes in metastatic behavior. The mutants were non-metastatic from an s.c. site of injection and poor organ-colonizers when administered i.v. Each of the mutant lines had the same lesion in N-linked oligosaccharide structure, which rendered the cells hypersensitive to the N-acetylglucosamine-binding lectin BSII in vitro. The phenotypic similarities between the 3 WGA-resistant isolates indicated that the mutation was directly related to the attenuated malignant phenotype. Direct confirmation was obtained by the isolation of a BSII-resistant clone of the mutant cells that co-reverted for lectin-sensitivity, lectin binding glycoproteins and malignant aggressiveness. The results indicate a direct relationship between malignant behavior and cell-surface oligosaccharide structure.

References

Apr 13, 1978·Proceedings of the Royal Society of London. Series B, Containing Papers of a Biological Character·M E Bramwell, H Harris
Feb 15, 1985·International Journal of Cancer. Journal International Du Cancer·J G CollardJ F Schijven
Jul 1, 1972·Proceedings of the National Academy of Sciences of the United States of America·L WarrenC A Buck
Jan 1, 1981·European Journal of Biochemistry·R Maget-DanaM Monsigny
Apr 15, 1982·International Journal of Cancer. Journal International Du Cancer·T W Tao, M M Burger

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Citations

Jan 1, 1987·Cancer Metastasis Reviews·J W Dennis, S Laferte
Jan 1, 1989·Pharmacology & Therapeutics·M J Humphries, K Olden
Dec 2, 1999·Biochimica Et Biophysica Acta·J W DennisC E Warren
Feb 1, 1991·Experimental Cell Research·I VanderElst, J W Dennis
Sep 1, 1999·British Journal of Cancer·R E SchwarzP B Paty
Jul 12, 2013·Fukushima Journal of Medical Science·Osamu Suzuki, Masafumi Abe

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