Co-selection of antibiotic and metal resistance
Abstract
There is growing concern that metal contamination functions as a selective agent in the proliferation of antibiotic resistance. Documented associations between the types and levels of metal contamination and specific patterns of antibiotic resistance suggest that several mechanisms underlie this co-selection process. These co-selection mechanisms include co-resistance (different resistance determinants present on the same genetic element) and cross-resistance (the same genetic determinant responsible for resistance to antibiotics and metals). Indirect but shared regulatory responses to metal and antibiotic exposure such as biofilm induction also represent potential co-selection mechanisms used by prokaryotes. Metal contamination, therefore, represents a long-standing, widespread and recalcitrant selection pressure with both environmental and clinical importance that potentially contributes to the maintenance and spread of antibiotic resistance factors.
Associated Clinical Trials
References
Involvement of the adc operon and manganese homeostasis in Streptococcus gordonii biofilm formation.
Elevated microbial tolerance to metals and antibiotics in metal-contaminated industrial environments
Citations
Effect of long-term zinc pollution on soil microbial community resistance to repeated contamination.
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