Co-signals in organ transplantation

Current Opinion in Organ Transplantation
Antoine DurrbachBernard Charpentier

Abstract

The nonimmune effects of currently used immunosuppressive drugs result in a high incidence of late graft loss due to nephrotoxicity and death. As an immune-specific alternative to conventional immunosuppressants, new biotechnology tools can be used to block the costimulation signal of T-cell activation. Many experimental studies, particularly preclinical studies in nonhuman primates, have focused on blocking 'classical' B7/CD28 and CD40/CD40L pathways, which are critical in primary T-cell activation, but also on new B7/CD28 and TNF/TNF-R pathways families of costimulatory molecules that can deliver positive or negative costimulation signals to regulate the alloimmune response. Belatacept is a new fusion protein derived from CTLA4-Ig that can be used to prevent acute rejection in renal transplantation instead of calcineurin inhibitors. Belatacept can also prevent acute rejection efficiently in humans and, more interestingly, can improve renal function and cardiovascular risk factors in this population.

References

Dec 1, 1995·The Journal of Experimental Medicine·G Del PreteS Romagnani
Sep 1, 1994·Immunology Today·F H DurieR J Noelle
May 1, 1995·Journal of Leukocyte Biology·S RomagnaniG Pizzolo
Jun 1, 1996·British Journal of Haematology·A YounesM Andreeff
Jun 10, 1997·Proceedings of the National Academy of Sciences of the United States of America·G NocentiniC Riccardi
Jun 1, 1997·Current Opinion in Immunology·C van Kooten, J Banchereau
Jun 10, 1998·The Journal of Experimental Medicine·K SaoulliT H Watts
Nov 25, 1998·Seminars in Immunology·R Horie, T Watanabe
Nov 25, 1998·Seminars in Immunology·D S Vinay, B S Kwon
Dec 22, 1999·The Journal of Immunology : Official Journal of the American Association of Immunologists·C A LondonA K Abbas
Jan 5, 2000·Nature·S K YoshinagaG Senaldi
Feb 12, 2000·European Journal of Immunology·I GramagliaM Croft
Sep 7, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·I GramagliaM Croft
Oct 6, 2000·The New England Journal of Medicine·U H von Andrian, C R Mackay
Oct 18, 2000·The Journal of Immunology : Official Journal of the American Association of Immunologists·Y MorelR T Costello
Feb 27, 2001·Nature Immunology·Y LatchmanG J Freeman
Jun 29, 2001·Nature Immunology·E OzkaynakW W Hancock
Jul 24, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·J L CannonsT H Watts
Nov 20, 2001·Nature Immunology·S K BromleyM L Dustin
Dec 12, 2001·The Journal of Immunology : Official Journal of the American Association of Immunologists·H C Wang, J R Klein
Feb 22, 2002·European Journal of Immunology·LauraL CarterBeatriz M Carreno
Jul 18, 2002·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Anna ValujskikhPeter S Heeger
Oct 9, 2002·Nature Immunology·Ursula GrohmannPaolo Puccetti
Oct 31, 2002·Nature Immunology·Erik B Finger, Jeffrey A Bluestone
Jan 23, 2003·Annals of the New York Academy of Sciences·Eckhard R PodackHiromi Muta
May 20, 2003·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·Jun WangKenneth A Newell
Jun 6, 2003·Cytokine & Growth Factor Reviews·Michael Croft
Sep 17, 2003·Nature Reviews. Immunology·Michael Croft
Nov 11, 2003·Proceedings of the National Academy of Sciences of the United States of America·Masahide ToneHerman Waldmann
Nov 25, 2003·Journal of Leukocyte Biology·Holly M ToenniesRobert H Arch
Jan 22, 2004·The Journal of Immunology : Official Journal of the American Association of Immunologists·Gülçin DemirciXian Chang Li

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Citations

May 21, 2013·Archivum Immunologiae Et Therapiae Experimentalis·Junyi ZhouJun Wu
Oct 31, 2013·Expert Review of Clinical Immunology·Mohammad H KarimiAli A Pourfathollah
Mar 29, 2011·Transplantation Proceedings·I Helal, L Chan
Dec 20, 2011·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·B E Burrell, J S Bromberg
May 28, 2011·Seminars in Immunology·Nina PilatThomas Wekerle
Mar 25, 2016·World Journal of Transplantation·Maria MessinaLuigi Biancone

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