Co-treatment of dichloroacetate, omeprazole and tamoxifen exhibited synergistically antiproliferative effect on malignant tumors: in vivo experiments and a case report

Hepato-gastroenterology
Tatsuaki IshiguroSayuri Iwai

Abstract

Omeprazole (OPZ) and tamoxifen (TAM) strengthen the effects of anticancer drugs and dichloroacetate (DCA) inhibits tumor growth. This study assesses the synergistic effects of these drugs. HT1080 human fibrosarcoma cells and WI-38 human fibroblasts were used as test and control cells, respectively. DCA, OPZ and TAM alone or in combination were applied and cells were counted after a one week culture. The combination of these drugs was prescribed to a cholangiocarcinoma patient and serum CA19-9 was monitored. DCA combined with OPZ and TAM exhibited more potent antitumor activity than DCA alone in HT1080 fibrosarcoma cells, but did not influence proliferation of WI-38 human fibroblasts. All these drugs induce caspase-dependent cell growth inhibition through superoxide production. Since they can be taken orally and have been used clinically without major side effects, it was thought that this combination therapy would be a readily translated strategy to treat malignant tumors. Under the patient's consent these three drugs were prescribed to a 51-year old female cholangiocarcinoma patient to whom neither gemcitabine+S-1 nor adoptive immunotherapy with natural killer cells was effective. Disease progression was successfully blocked (...Continue Reading

Citations

Mar 9, 2013·Cell Death & Disease·Y ZhaoM Tan
Mar 13, 2015·Investigational New Drugs·Quincy Siu-Chung ChuEvangelos D Michelakis
Nov 3, 2016·World Journal of Clinical Cases·Akbar KhanAnneke C Blackburn
May 4, 2017·World Journal of Gastroenterology : WJG·Jin-Liang ZhangGuo-Liang Xu

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