Co-treatment of wild-type EGFR head and neck cancer cell lines with afatinib and cisplatin

Molecular Medicine Reports
Roman C BrandsStefan Hartmann

Abstract

Treatment of head and neck squamous cell carcinoma (HNSCC) remains challenging. Non‑surgical approaches typically comprise radiotherapy and antineoplastic chemotherapy, of which platinum‑based agents are the most common. Similar to other malignancies, targeted therapies have an increasing role in the treatment of head and neck cancer. The overexpression of epidermal growth factor receptor (EGFR) is a useful target for specific therapeutic strategies. Resistance to EGFR‑directed therapies, including cetuximab, is partly mediated by the activation of alternative receptors and pathways. Therefore, other members of the ErbB family, including human epidermal growth factor receptor (HER)2 and HER4, may have important therapeutic roles. The aim of the present study was to investigate the efficacy of afatinib, an EGFR/HER2/HER4 tyrosine kinase inhibitor, in combination with cisplatin in HNSCC cell lines. The cisplatin concentration used was set at cell line‑specific half maximal inhibitory concentration values. Since the vast majority of head and neck cancers do not exhibit any EGFR tyrosine kinase domain mutations, five human EGFR wild‑type HNSCC cell lines were used in the present study. For statistical analyses, non‑parametric Mann‑...Continue Reading

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Citations

Feb 23, 2018·Oncology Letters·Roman C BrandsUrs D A Müller-Richter
Feb 9, 2017·Cancer Control : Journal of the Moffitt Cancer Center·Ozlen SaglamAnthony M Magliocco

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