PMID: 9530901Apr 8, 1998Paper

Co-trimoxazole desensitization in HIV-seropositive patients

International Journal of STD & AIDS
C M TheodoreK A McLean

Abstract

Co-trimoxazole (trimethoprim-sulphamethoxazole) is an effective prophylactic agent against Pneumocystis carinii pneumonia (PCP). However, it is associated with a high frequency of adverse reactions in immunocompromised patients which may preclude its use. Fourteen patients with a definite history of adverse reactions to co-trimoxazole on standard PCP prophylactic dosage were selected for desensitization using a regimen of gradual incremental exposure over an 11-day period. Eight (57.1%) were successfully desensitized and have continued on oral co-trimoxazole at maximum 21 months' follow-up. This report demonstrates that oral desensitization as an outpatient procedure is an effective and safe option for both primary and secondary PCP prophylaxis in HIV-seropositive patients with previous adverse drug reactions.

Citations

Aug 19, 2010·Allergy·J R CernadasUNKNOWN European Network of Drug Allergy and the EAACI interest group on drug hypersensitivity
Mar 16, 2002·The Annals of Pharmacotherapy·Elizabeth J PhillipsSandra R Knowles
Nov 28, 2019·Expert Review of Clinical Immunology·Lucia DiaferioDavide Caimmi

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