CO2 abdominal insufflation decreases local and systemic inflammatory response in experimental acute pancreatitis

Pancreas
Marcel Cerqueira Cesar MachadoSonia Jancar

Abstract

Acute pancreatitis (AP) is a serious disease that is amplified by an associated systemic inflammatory response. We investigated the effect of CO2 pneumoperitoneum on the local and systemic inflammatory response in AP. Acute pancreatitis was induced in Wistar rats by 5% taurocholate intraductal injection. Carbon dioxide pneumoperitoneum was applied for 30 minutes before the induction of AP. Inflammatory parameters were evaluated in the peritoneum (ascites, cell number, and tumor necrosis factor alpha [TNF-alpha]), serum (amylase, TNF-alpha, interleukin-6 [IL-6], and IL-10), pancreas (myeloperoxidase [MPO] activity, cyclo-oxygenase 2 and inducible nitric oxide synthase expression, and histological diagnosis), liver, and lung (mitochondria dysfunction and MPO activity). Abdominal insufflation with CO2 before induction of AP caused a significant decrease in ascites volume, cells, and TNF-alpha in the peritoneal cavity and in serum TNF-alpha and IL-6 but not IL-10 levels. In the pancreas, this treatment reduced MPO activity, acinar and fat necrosis, and the expression of inducible nitric oxide synthase and cyclo-oxygenase 2. There were no significant differences on serum amylase levels, liver mitochondrial function, and pulmonary MP...Continue Reading

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Citations

Jul 23, 2011·Antioxidants & Redox Signaling·Péter Hegyi, Zoltán Rakonczay
Aug 5, 2010·Pancreas·Lourenilson José SouzaMarcel Cerqueira Cesar Machado
Mar 8, 2013·Annals of Surgical Oncology·Marcel Autran MachadoRodrigo C Surjan
Sep 26, 2015·International Journal of Surgery·O A MynbaevM Yu Eliseeva
Mar 6, 2013·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Edmond Raymond Le CampionLuiz Augusto Carneiro D'Albuquerque
Jul 5, 2012·Acta Cirúrgica Brasileira·Ana Maria Mendonça CoelhoJosé Jukemura

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