CO2/HCO3 - Accelerates Iron Reduction through Phenolic Compounds.

MBio
Felix MüllerBastian Blombach

Abstract

Iron is a vital mineral for almost all living organisms and has a pivotal role in central metabolism. Despite its great abundance on earth, the accessibility for microorganisms is often limited, because poorly soluble ferric iron (Fe3+) is the predominant oxidation state in an aerobic environment. Hence, the reduction of Fe3+ is of essential importance to meet the cellular demand of ferrous iron (Fe2+) but might become detrimental as excessive amounts of intracellular Fe2+ tend to undergo the cytotoxic Fenton reaction in the presence of hydrogen peroxide. We demonstrate that the complex formation rate of Fe3+ and phenolic compounds like protocatechuic acid was increased by 46% in the presence of HCO3 - and thus accelerated the subsequent redox reaction, yielding reduced Fe2+ Consequently, elevated CO2/HCO3 - levels increased the intracellular Fe2+ availability, which resulted in at least 50% higher biomass-specific fluorescence of a DtxR-based Corynebacterium glutamicum reporter strain, and stimulated growth. Since the increased Fe2+ availability was attributed to the interaction of HCO3 - and chemical iron reduction, the abiotic effect postulated in this study is of general relevance in geochemical and biological environments....Continue Reading

References

Jan 1, 1992·Life Sciences·M Lyte, S Ernst
Mar 1, 1988·Journal of Inorganic Biochemistry·R F BoyerA P LaRoche
Feb 1, 1968·Journal of Bacteriology·W J Peters, R A Warren
Sep 3, 1968·Biochimica Et Biophysica Acta·W J Peters, R A Warren
Jan 1, 1981·Annual Review of Biochemistry·J B Neilands
Apr 1, 1993·Clinical Microbiology Reviews·C M Litwin, S B Calderwood
Feb 1, 1997·Infection and Immunity·K J NyhusE S Jacobson
Aug 26, 1998·Biochemical and Biophysical Research Communications·V CoulangesD J Vidon
Jan 17, 2002·Journal of the American Chemical Society·Katherine BarbeauAlison Butler
Jun 28, 2003·FEMS Microbiology Reviews·Simon C AndrewsFrancisco Rodríguez-Quiñones
Jun 28, 2003·FEMS Microbiology Reviews·Imke SchröderSimon de Vries
Jan 15, 2004·The Biochemical Journal·Huangen Ding, Robert J Clark
Sep 24, 2004·Journal of Molecular Microbiology and Biotechnology·Masayuki InuiHideaki Yukawa
Aug 17, 2005·FEMS Microbiology Reviews·Uwe Sauer, Bernhard J Eikmanns
Apr 6, 2006·Journal of Bacteriology·Julia Wennerhold, Michael Bott
Sep 14, 2007·International Journal of Food Microbiology·Primrose P E FreestoneMark Lyte
Apr 9, 2008·Journal of Bacteriology·Mark T Anderson, Sandra K Armstrong
May 20, 2008·Applied and Environmental Microbiology·Kenji UedaTeruhiko Beppu
Sep 9, 2008·Applied Microbiology and Biotechnology·Shohei OkinoHideaki Yukawa
Feb 3, 2009·Cell Biochemistry and Biophysics·Nathan R Perron, Julia L Brumaghim
Apr 21, 2009·Applied and Environmental Microbiology·Haruhiko TeramotoHideaki Yukawa
Jan 11, 2011·Journal of Bacteriology·Julia FrunzkeMichael Bott
May 24, 2011·Methods in Enzymology·Daniel G Gibson
Aug 15, 2012·Biotechnology and Bioengineering·Alexander GrünbergerStephan Noack
Sep 3, 2013·Biotechnology and Bioengineering·Simon UnthanStephan Noack

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Citations

Dec 12, 2020·Microorganisms·Tatjana WalterVolker F Wendisch
Aug 17, 2021·Frontiers in Bioengineering and Biotechnology·Daniel SiebertBastian Blombach

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Methods Mentioned

BETA
PCA
PCR

Software Mentioned

MassHunter

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