COA-Cl (2-Cl-C.OXT-A) can promote coronary collateral development following acute myocardial infarction in mice

Scientific Reports
Toshiyuki NishikidoKoichi Node

Abstract

2-Cl-C.OXT-A (COA-Cl) is a novel nucleic acid analogue that promotes tube-forming activity of human umbilical vein endothelial cells (HUVEC) through vascular endothelial growth factor (VEGF). The development of coronary collateral circulation is critical to rescue the ischemic myocardium and to prevent subsequent irreversible ischemic injury. We evaluated whether COA-Cl can promote angiogenesis in ischemic tissue, reduce infarct size and preserve cardiac contractility in vivo. Mice received COA-Cl or placebo daily for three days after myocardial infarction (MI) by coronary ligation. The degree of angiogenesis in ischemic myocardium was assessed by staining endothelial cells and vascular smooth muscle cells, and measuring infarct size/area-at-risk. In mice treated with COA-Cl, enhanced angiogenesis and smaller infarct size were recognized, even given a similar area at risk. We observed increases in the protein expression levels of VEGF and in the protein phosphorylation level of eNOS. In addition, the heart weight to body weight ratio and myocardial fibrosis in COA-Cl mice were decreased on Day 7. Administration of COA-Cl after MI promotes angiogenesis, which is associated with reduced infarct size and attenuated cardiac remodel...Continue Reading

References

Feb 28, 2001·Proceedings of the National Academy of Sciences of the United States of America·D FukumuraR K Jain
Jun 29, 2001·European Heart Journal·R Tabibiazar, S G Rockson
Mar 19, 2003·Circulation·Timothy D HenryUNKNOWN VIVA Investigators
Jun 5, 2003·Nature Medicine·Rakesh K Jain
Jul 5, 2005·Journal of Molecular and Cellular Cardiology·S VanderveldeM C Harmsen
Dec 15, 2007·Cardiovascular Research·Victor W M van Hinsbergh, Pieter Koolwijk
Feb 9, 2008·Circulation Research·Krishnan VenkataramanTimothy Hla
Dec 2, 2009·Nature Reviews. Cardiology·Susanne W M van den BorneJagat Narula
Aug 10, 2010·Biochemical and Biophysical Research Communications·Ikuko TsukamotoRyoji Konishi
Mar 20, 2012·American Journal of Physiology. Heart and Circulatory Physiology·Jun-ichi OyamaNaoki Makino
Nov 5, 2013·Physiology·Andriy YabluchanskiyMerry L Lindsey
Sep 4, 2015·Chemical & Pharmaceutical Bulletin·Norikazu SakakibaraIkuko Tsukamoto

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Citations

Mar 23, 2019·American Journal of Physiology. Heart and Circulatory Physiology·Sherin Ali NawaitoBruce G Allen

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Methods Mentioned

BETA
confocal microscopy

Software Mentioned

SPSS
Image J

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