PMID: 9177480May 2, 1997Paper

Coactivation of human alpha1- and alpha2-globin genes in single induced MEL cells containing one human alpha-globin locus

Biochimica Et Biophysica Acta
C EspéretF Morlé

Abstract

We developed a reverse-transcription polymerase chain reaction assay, performed on single isolated cells, to demonstrate the coexpression of human alpha1- and alpha2-globin mRNA in induced mouse erythroleukemic cells containing a single human alpha-globin locus. These results indicate that both alpha1 and alpha2 genes are activated from the same alpha-globin gene locus implying that HS-40-dependent transcriptional activation is mediated, either by a simultaneous interaction of HS-40 with both a alpha1 and alpha2-globin gene promoters, or by a dynamic process characterized by alternative, but short-lived, interactions with each alpha-globin gene promoter.

References

Jan 1, 1976·Birth Defects Original Article Series·W F AndersonR S Kucherlapati
Jan 1, 1986·Cold Spring Harbor Symposia on Quantitative Biology·B Royer-PokoraS H Orkin
Nov 15, 1996·Genes & Development·M WijgerdeP Fraser

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Citations

Jan 7, 2003·International Journal of Hematology·Hua-bing ZhangChih-Chuan Liang
Apr 28, 2005·Blood·Sung-Ho GohJeffery L Miller

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