PMID: 9445082Jan 28, 1998Paper

Coadministration of DNA encoding interleukin-6 and hemagglutinin confers protection from influenza virus challenge in mice

Journal of Virology
D L LarsenC W Olsen

Abstract

This study was conducted to investigate whether Accell gene gun coadministration of DNA encoding human interleukin-6 (IL-6) would enhance protective immune responses in mice to an equine influenza A virus hemagglutinin (HA) DNA vaccine. Mice that received HA DNA alone exhibited accelerated clearance of homologous challenge virus but were not protected from infection. In contrast, mice that received both HA and IL-6 DNA had no detectable virus in their lungs after challenge. These results strongly support the use of IL-6 as a cytokine adjuvant in DNA vaccination.

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Citations

Jun 3, 2000·Annual Review of Immunology·S GurunathanR A Seder
Dec 23, 2006·Expert Review of Vaccines·Wolfgang Jechlinger
Jan 11, 2007·Immunology and Cell Biology·Nicole L La GrutaPeter C Doherty
May 2, 2007·Current Opinion in Infectious Diseases·Raghavan U M PalaniappanYung-Fu Chang
Mar 13, 2001·Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research·S Esnault, J S Malter
Jul 4, 2002·The Veterinary Quarterly·C van Maanen, A Cullinane
Sep 3, 2009·Expert Review of Vaccines·Eric J YagerDeborah Heydenburg Fuller
Sep 11, 2004·Viral Immunology·Edwin D Kilbourne
May 6, 2019·Vaccines·Ashish C ShresthaBranka Grubor-Bauk
Mar 23, 2000·FEMS Immunology and Medical Microbiology·E Medina, C A Guzmán
Jun 25, 2017·Veterinary Research·Irshad A HajamJohn Hwa Lee
Jul 6, 2017·International Journal of Molecular Sciences·Ming GuoWenbin Zhan
Jul 25, 2018·Frontiers in Immunology·Leo Yi Yang LeeAeron C Hurt
Oct 12, 2000·Biochemical and Biophysical Research Communications·I TodorokiM Itoh
Mar 21, 2001·Vaccine·J Y Scheerlinck
Aug 17, 1999·Journal of Clinical Microbiology·L Oxburgh, B Klingeborn

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