Coadministration of huperzine A and ligustrazine phosphate effectively reverses scopolamine-induced amnesia in rats

Pharmacology, Biochemistry, and Behavior
Jun ShiGuoan Luo

Abstract

In the present study, whether coadministration of huperzine A (HA) and ligustrazine phosphate (LP) could effectively improve the memory deficits in association with ameliorating cholinergic impairment and oxidative stress in the scopolamine-induced amnesia rats was assessed. The effects of treatment with Coa [HA (0.14 mg/kg, i.g.) and LP (110 mg/kg, i.g.)] on amnesia were investigated in Morris water maze. Furthermore, the effects on the activities of acetylcholinesterase (AChE) and antioxidant enzymes within the cerebral cortex and hippocampus were evaluated, and the lipid peroxidation product malondialdehyde (MDA) was also analyzed. As a result, coadministration of HA and LP for 10 consecutive days could markedly reverse the scopolamine-induced learning and memory impairment determined by the Morris water maze test. Moreover, AChE activity was significantly inhibited, and superoxide dismutases (SOD) and glutathione peroxidase (GSH-Px) activities were significantly increased with a remarkable reduction in the level of MDA. In conclusion, coadministration of HA and LP effectively prevented cholinergic impairment and oxidative damage, thereby resulting in improvement of spatial learning memory in rats induced by scopolamine. The...Continue Reading

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Citations

Mar 2, 2016·Phytomedicine : International Journal of Phytotherapy and Phytopharmacology·Changrun GuoFei Li
Jan 30, 2016·Journal of Drug Targeting·Ming-Hua DuanZhi-Dong Qiu
Jan 8, 2013·Pharmacology, Biochemistry, and Behavior·Hong-Mei WangAhsana-Dar Farooq
May 18, 2018·Evidence-based Complementary and Alternative Medicine : ECAM·Chang-Yul KimJung-Hee Jang
Oct 30, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Sajad FakhriEduardo Sobarzo-Sánchez

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