Coagulase-negative staphylococci in a major Danish university hospital: diversity in antibiotic susceptibility between wards

APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica
J O Jarløv, N Høiby

Abstract

Over a one-year period, all coagulase-negative staphylococci (CoNS) from blood cultures, cerebrospinal fluids and peritoneal effluents from patients in a major Danish university hospital were investigated for susceptibility to penicillin G; methicillin; gentamicin; netilmicin; amikacin; erythromycin; clindamycin; fusidic acid; rifampicin; tetracycline; chloramphenicol; ciprofloxacin; teicoplanin; and vancomycin. Among the CoNS-isolates, 56% were resistant to methicillin, 51% to gentamicin, 28% to ciprofloxacin, and 5% to teicoplanin. Blood culture CoNS-isolates from patients with a central venous catheter (CVC) were more often resistant to various antibiotics compared to CoNS-isolates from patients without a CVC, e.g. methicillin (72% vs 21%), gentamicin (65% vs 22%) (p<0.00000001). Great diversity in antibiotic resistance between the wards was found; methicillin resistance (in most cases multiple antibiotic resistance) was in particular associated with consumption of broad-spectrum beta-lactams, quinolones, and total antibiotic consumption in a ward. Thus, the antibiotic policy of a ward is an important factor for antibiotic resistance among CoNS.

References

Sep 1, 1992·The Journal of Hospital Infection·K Refsahl, B M Andersen
Nov 1, 1991·The Journal of Antimicrobial Chemotherapy·G Hedin, A Hambraeus
Feb 1, 1991·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·V T Rosdahl, A M Knudsen
Oct 1, 1990·The Journal of Antimicrobial Chemotherapy·R P MoutonB van Klingeren
Dec 1, 1989·The Journal of Antimicrobial Chemotherapy·J K Møller
Aug 1, 1994·Clinical Infectious Diseases : an Official Publication of the Infectious Diseases Society of America·M E Rupp, G L Archer
Apr 1, 1994·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·J O JarløvF Espersen
Jun 1, 1996·APMIS : Acta Pathologica, Microbiologica, Et Immunologica Scandinavica·A KjerulfH Westh

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Citations

Jan 12, 2011·European Journal of Clinical Microbiology & Infectious Diseases : Official Publication of the European Society of Clinical Microbiology·K KristófF Rozgonyi
Dec 12, 2001·International Journal of Antimicrobial Agents·E PetinakiUNKNOWN Bacterial Resistance Study Group
Aug 26, 1999·International Journal of Antimicrobial Agents·J M Cristino
Feb 22, 2003·Surgical Infections·P S Barie
Dec 6, 2005·The Journal of Hospital Infection·S J DancerS Alcock
Feb 8, 2005·Infection Control and Hospital Epidemiology : the Official Journal of the Society of Hospital Epidemiologists of America·Tor MonsenJohan Wiström
Oct 30, 2004·Current Opinion in Pulmonary Medicine·Ronald J DeBellis

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