PMID: 11913569Mar 27, 2002Paper

Coagulation abnormalities and acquired von Willebrand's disease type 1 in children receiving valproic acid

Journal of Child Neurology
Gül SerdarogluHasan Tekgül

Abstract

Valproic acid is commonly used in the management of childhood epilepsy. The known hematologic side effects of the drug are hemorrhagic diatheses, thrombocytopenia, and hypofibrinogenemia. We studied coagulation parameters in 29 epileptic children receiving valproic acid for at least 6 months. Their ages ranged between 2 and 18 years (10.2 +/- 4.9 years). The total valproic acid dose was 250 to 1000 mg/day equivalent to 20 to 30 mg/kg/day. Treatment duration ranged from 6 to 57 months. These children had not previously had a hemostatic defect and had no family history of bleeding disorders. Platelet count, prothrombin time, activated partial thromboplastin time, bleeding time, fibrinogen, platelet aggregation assays, and ristocetin cofactor activity levels were determined in all of the patients, but von Willebrand's factor antigen levels could be determined in only 14 patients. The values of von Willebrand's factor antigen ranged from 53 to 218% (104.1 +/- 42.3), and ristocetin cofactor activity levels ranged from 11.5 to 218% (94.5 +/- 43.1). Six of the 29 children (20.7%) had decreased values of ristocetin and cofactor activity and were considered to have acquired von Willebrand's disease. The decreases in coagulation paramete...Continue Reading

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Citations

Nov 13, 2002·Pharmacoepidemiology and Drug Safety
Jan 10, 2013·Pharmacological Reviews·Chi-Tso ChiuDe-Maw Chuang
Apr 15, 2009·PloS One·David A HanauerArul M Chinnaiyan
Aug 27, 2013·Drug Design, Development and Therapy·Hai-Fei ChenZhao-Yue Wang
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Dec 24, 2010·Journal of Pediatric Endocrinology & Metabolism : JPEM·Ozgür OlukmanKaan Kavakli
Dec 23, 2016·Pediatrics International : Official Journal of the Japan Pediatric Society·Burcu KarakayalıIsmail Islek
Oct 12, 2014·Human & Experimental Toxicology·S OktayA Yarat
Jun 2, 2009·Journal of Child Neurology·Gülsen KöseTulin R Sayli
Jul 5, 2008·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·Stephan KoenigCarl-Erik Dempfle
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Aug 16, 2021·Hematology/oncology Clinics of North America·Arielle L Langer, Nathan T Connell

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