Coagulation and inflammation in overt diabetic nephropathy: association with hyperhomocysteinemia

Clinica Chimica Acta; International Journal of Clinical Chemistry
Yoshimasa AsoToshihiko Inukai

Abstract

Diabetic nephropathy, especially when advanced, is associated with high prevalence of atherosclerotic cardiovascular disease in which inflammation and coagulation may play pathogenic roles. We investigated the relationships between diabetic nephropathy and coagulation, fibrinolysis, or inflammation in patients with Type 2 diabetes. We evaluated markers of inflammation and coagulation in 105 Type 2 diabetic patients with various grades of nephropathy and 49 healthy control subjects, in association with plasma total homocysteine (tHcy) measurements. Plasma tHcy concentrations were significantly higher in diabetic patients than in controls (8.96 +/- 3.04 vs. 6.92 +/- 1.36 micromol/l, P < 0.0001). Plasma concentrations of interleukin (IL)-6 were significantly higher in diabetic patients than in control subjects (P < 0.0001). In diabetic patients, plasma tHcy correlated positively with urinary albumin, fibrinogen, IL-6 and plasmin-alpha2-antiplasmin complex (PAP), while plasma tHcy correlated negatively with creatinine clearance (Ccr) and protein C activity. After adjustment for Ccr, IL-6 and protein C activity were significantly associated with plasma tHcy. Plasma tHcy concentrations were significantly higher in patients with overt...Continue Reading

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Citations

Sep 13, 2012·Mediators of Inflammation·Andy K H Lim, Gregory H Tesch
Sep 21, 2011·PloS One·Peter S KimColleen Hadigan
Feb 19, 2014·Clinica Chimica Acta; International Journal of Clinical Chemistry·Song MaoAihua Zhang
Oct 17, 2007·Clinical Chemistry and Laboratory Medicine : CCLM·Hieronim Jakubowski
Dec 21, 2007·Biomedicine & Pharmacotherapy = Biomédecine & Pharmacothérapie·P BogdanskiH Jakubowski
Mar 12, 2010·Diabetes/metabolism Research and Reviews·Agnès MathesonBradley J Walsh
Oct 10, 2006·Nutrition, Metabolism, and Cardiovascular Diseases : NMCD·Gjin NdrepepaAlbert Schömig
May 29, 2016·International Journal of Biological Macromolecules·Yingjie XuDelin Duan
Oct 11, 2017·Nephrology, Dialysis, Transplantation : Official Publication of the European Dialysis and Transplant Association - European Renal Association·Kevin M WheelockRobert G Nelson
Apr 8, 2018·Clinical Science·Montserrat Baldan-MartinGema Ruiz-Hurtado
Jan 10, 2021·Journal of Diabetes and Its Complications·Emir MuzurovićDimitri P Mikhailidis

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