Coagulation defects do not predict blood product requirements during liver transplantation

Transplantation
Luc MassicotteAndré Roy

Abstract

In our experience, correction of coagulation defects with plasma transfusion does not decrease the need for intraoperative red blood cell (RBC) transfusions during liver transplantation. On the contrary, it leads to a hypervolemic state that result in increased blood loss. A previous study has shown that plasma transfusion has been associated with a decreased 1-year survival rate. The aim of this prospective study was to evaluate whether anesthesiologists could reduce RBC transfusion requirements during liver transplantation by eliminating plasma transfusion. Two hundred consecutive liver transplantations were prospectively studied over a 3-year period. Patients were divided into two groups: low starting international normalized ratio (INR) value <1.5 and high INR > or =1.5. Low central venous pressure was maintained in all patients before the anhepatic phase. Coagulation parameters were not corrected preoperatively or intraoperatively in the absence of uncontrollable bleeding. Phlebotomy and auto transfusion of blood salvaged were used following our protocol. Independent variables were analyzed in both univariate and multivariate fashion to find a link with RBC transfusions or decreased survival rate. The mean number of intrao...Continue Reading

References

Mar 1, 1985·Transfusion·P ButlerT E Starzl
Jan 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A L BoksH H Van Vliet
Oct 1, 1996·Anesthesia and Analgesia·J DupontP Scherpereel
Feb 2, 1999·Archives of Surgery·T V CacciarelliC O Esquivel
Aug 23, 2003·Anesthesia and Analgesia·Yves OzierUNKNOWN French Study Group on Blood Transfusion in Liver Transplantation
Nov 20, 2003·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Emilio RamosEduardo Jaurrieta
Apr 24, 2004·Anesthesia and Analgesia·Luc MassicotteAndré Roy
Sep 25, 2004·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·James F TrotterCharles Phillips
Feb 3, 2005·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Luc MassicotteAndré Roy
Feb 18, 2005·Transplant International : Official Journal of the European Society for Organ Transplantation·H G D HendriksM J H Slooff
Feb 24, 2005·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Armando TripodiPier Mannuccio Mannucci
May 6, 2005·Canadian Journal of Anaesthesia = Journal Canadien D'anesthésie·Luc MassicotteAndré Roy
Jul 22, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Raymond M PlaninsicSukru Emre
Jul 22, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·J Peter A LodgeUNKNOWN rFVIIa OLT Study Group
Dec 31, 2005·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Luc MassicotteAndré Roy
Jan 6, 2006·The New England Journal of Medicine·Robert Steinbrook
Jan 27, 2006·The New England Journal of Medicine·Dennis T ManganoUNKNOWN Ischemia Research and Education Foundation
Jul 28, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Armando TripodiPier Mannuccio Mannucci
Sep 29, 2006·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Stephen H CaldwellUNKNOWN Coagulation in Liver Disease Group
Jan 18, 2007·American Journal of Transplantation : Official Journal of the American Society of Transplantation and the American Society of Transplant Surgeons·I Q MolenaarR J Porte
Mar 12, 2008·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Luc MassicotteAndré Roy

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Citations

Dec 18, 2013·British Journal of Anaesthesia·D KiamaneshV K Moitra
Jun 9, 2009·Transplantation·Luc MassicotteAndré Roy
Dec 3, 2013·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Gil Cunha De SantisOrlando de Castro e Silva
Apr 1, 2014·Langenbeck's Archives of Surgery·Benedikt ReichertHarald Schrem
Mar 1, 2011·Annales Françaises D'anesthèsie Et De Rèanimation·S RoulletF Sztark
Apr 12, 2014·Transfusion Medicine Reviews·Pepijn D WeederTon Lisman
Mar 21, 2009·Current Opinion in Organ Transplantation·Antònia DalmauIdoia Aparicio
May 10, 2013·European Journal of Anaesthesiology·Sibylle A Kozek-LangeneckerPiet Wyffels
Feb 6, 2016·Abdominal Radiology·Kumaresan SandrasegaranPaul Kwo
Dec 6, 2014·Acta Anaesthesiologica Taiwanica : Official Journal of the Taiwan Society of Anesthesiologists·Bruno JawanSheng-Chun Yang
Apr 29, 2015·Clinica Chimica Acta; International Journal of Clinical Chemistry·Antonio Leon-JustelJuan M Guerrero
Mar 26, 2013·Transfusion clinique et biologique : journal de la Société française de transfusion sanguine·Y OzierA Dovergne
Nov 14, 2012·Transplantation Proceedings·M Esmat GamilF Nevens
Sep 29, 2015·Revista española de anestesiología y reanimación·P MelladoM A Gómez
Jun 21, 2012·Critical Care Clinics·Kevin Dasher, James F Trotter
Oct 10, 2009·HPB : the Official Journal of the International Hepato Pancreato Biliary Association·Andrie C WesterkampRobert J Porte
Apr 26, 2011·Transplantation Reviews·Linda L Liu, Claus U Niemann
Dec 4, 2010·Transplantation Reviews·Michael J Hannaman, Zoltan G Hevesi
Apr 21, 2010·Best Practice & Research. Clinical Anaesthesiology·Daryl J KorOgnjen Gajic
Aug 25, 2015·Transfusion and Apheresis Science : Official Journal of the World Apheresis Association : Official Journal of the European Society for Haemapheresis·Chang LiuBrenda J Grossman
Dec 17, 2014·HPB Surgery : a World Journal of Hepatic, Pancreatic and Biliary Surgery·Maxwell A ThompsonDerek A DuBay
Feb 1, 2011·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Alexander B BensonMarc Moss
Sep 7, 2012·Anaesthesia·J R Klinck, L T T Pan
May 4, 2013·Liver International : Official Journal of the International Association for the Study of the Liver·Susan V MallettAndrew K Burroughs
Jun 26, 2012·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Shen-Chih WangMei-Yung Tsou
Jan 29, 2013·Transplant International : Official Journal of the European Society for Organ Transplantation·Jochen HerrmannKnut Helmke
Apr 12, 2011·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·Sujith V W WeerasingheM Bishr Omary
Nov 26, 2009·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·James D Perkins
Mar 26, 2016·Digestive and Liver Disease : Official Journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver·UNKNOWN Under the auspices of the Italian Association for the Study of Liver Diseases (AISF) and the Italian Society of Internal Med
Jan 21, 2015·BJOG : an International Journal of Obstetrics and Gynaecology·B W PrickUNKNOWN EBM Connect Collaboration
Aug 1, 2015·European Journal of Gastroenterology & Hepatology·Wilma Debernardi VenonAlfredo Marzano
Nov 6, 2014·Liver Transplantation : Official Publication of the American Association for the Study of Liver Diseases and the International Liver Transplantation Society·Nobuhisa AkamatsuNorihiro Kokudo
Dec 3, 2014·Anaesthesia·S V Mallett, M Armstrong
Jul 8, 2015·Journal of Thrombosis and Haemostasis : JTH·L Raffini, C Witmer
Jun 16, 2010·Journal of Hepatology·Ton LismanUNKNOWN Coagulation in Liver Disease Study Group
Aug 9, 2016·Transplantation Direct·James YipGabriel T Schnickel
May 21, 2011·Revista brasileira de anestesiologia·Bruno Salomé de MoraisGuilherme Henrique Gomes Moreira Cançado
Apr 2, 2015·Saudi Journal of Anaesthesia·Shweta A SinghAjeet Singh Bhadoria

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