Coagulation-dependent mechanisms and asthma

The Journal of Clinical Investigation
Michael A Matthay, John A Clements

Abstract

In several clinical disorders, there are interactions between inflammation-dependent tissue injury and thrombin formation, fibrin deposition, and impaired fibrinolysis. New evidence generated from a mouse model of allergic airway hyperreactivity suggests that disordered coagulation and fibrinolysis may contribute to the pathogenesis of asthma. The inflammatory mechanisms that lead to airway smooth muscle contraction and airway hyperresponsiveness may be associated with accumulation of extravascular fibrin, plasma exudates, and inflammatory cells that can lead to airway closure.

References

Feb 1, 1989·Respiration Physiology·R D Kamm, R C Schroter
Oct 1, 1967·Circulation Research·T BayleyA J Osbahr
Jun 29, 1999·Lung·E C GabazzaY Adachi
Jul 3, 1999·American Journal of Respiratory and Critical Care Medicine·N N Jarjour, G Enhorning
Mar 10, 2001·The New England Journal of Medicine·G R BernardUNKNOWN Recombinant human protein C Worldwide Evaluation in Severe Sepsis (PROWESS) study group
Jan 22, 2003·Virchows Archiv : an International Journal of Pathology·A SchmiedlJ M Hohlfeld
Jan 30, 2003·Annals of Medicine·Charles T Esmon
Feb 6, 2003·The Journal of Clinical Investigation·Jack A EliasZhou Zhu
May 20, 2003·American Journal of Physiology. Lung Cellular and Molecular Physiology·Lorraine B WareMichael A Matthay
Jun 12, 2003·The European Respiratory Journal·K S BabuJ H Conway
Jul 18, 2003·The American Journal of Medicine·Steven R Hays, John V Fahy
Apr 21, 2004·Proceedings of the National Academy of Sciences of the United States of America·Katerina AkassoglouSidney Strickland
Jul 3, 2004·The Journal of Clinical Investigation·Scott S WagersCharles G Irvin

❮ Previous
Next ❯

Citations

Jul 20, 2010·American Journal of Respiratory and Critical Care Medicine·Livia A VeressCarl W White
Jun 24, 2006·American Journal of Respiratory Cell and Molecular Biology·Eric K ChuJeffrey M Drazen
Dec 4, 2014·European Journal of Internal Medicine·Wei-Sheng ChungChia-Hung Kao
Apr 9, 2014·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·C Page, S Pitchford
Dec 21, 2010·Seminars in Arthritis and Rheumatism·Anna Ludwicka-BradleyGalina S Bogatkevich
Sep 16, 2008·Clinical Immunology : the Official Journal of the Clinical Immunology Society·Shino ShimizuEsteban C Gabazza
Jun 26, 2009·Journal of Thrombosis and Haemostasis : JTH·M SchoutenJ S VAN DER Zee
Sep 11, 2014·European Journal of Clinical Investigation·Wei-Sheng ChungChia-Hung Kao
Mar 10, 2010·Clinical and Experimental Allergy : Journal of the British Society for Allergy and Clinical Immunology·D EwenJ K Shute
Dec 26, 2013·Allergology International : Official Journal of the Japanese Society of Allergology·Masaaki TodaJohn Morser

❮ Previous
Next ❯

Methods Mentioned

BETA
bronchoalveolar lavage
bronchoalveolar
lavage

Related Concepts

Related Feeds

Asthma

This feed focuses in Asthma in which your airways narrow and swell. This can make breathing difficult and trigger coughing, wheezing and shortness of breath.

Allergy and Asthma

Allergy and asthma are inflammatory disorders that are triggered by the activation of an allergen-specific regulatory t cell. These t cells become activated when allergens are recognized by allergen-presenting cells. Here is the latest research on allergy and asthma.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
Antonella NaldiniFabio Carraro
The Journal of Asthma : Official Journal of the Association for the Care of Asthma
Fraser J H BrimsJanis K Shute
American Journal of Respiratory and Critical Care Medicine
Birgitte F SodeBørge G Nordestgaard
FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology
Junhang ZhangEric Wahlberg
© 2022 Meta ULC. All rights reserved