Coagulation disorders after traumatic brain injury: pathophysiology and therapeutic implications

Annales Françaises D'anesthèsie Et De Rèanimation
T GeeraertsB Vigué

Abstract

Early activation of coagulation is common after traumatic brain injury. Its origin is probably mainly intracerebral, due to tissue factor release from the injured brain. Abnormalities in blood coagulation tests are associated with poor neurological prognosis. Coagulation activation may induce disseminated intravascular coagulation and fibrinolysis. Disseminated intravascular coagulation is linked to brain ischemia caused by intravascular microthrombosis. This review will focus on pathophysiology of coagulation disorders after traumatic brain injury, and on their implications for therapeutic approaches.

References

Dec 1, 1992·Journal of Neurosurgery·J PiekM A Foulkes
Mar 1, 1989·Journal of Neurology, Neurosurgery, and Psychiatry·D I GrahamD R McLellan
Jan 15, 1998·Critical Care Medicine·R U Scherer, P Spangenberg
Jan 6, 2001·Journal of Neurosurgical Anesthesiology·M S VavilalaA M Lam
Oct 5, 2001·The Journal of Trauma·R C JacobyT G Paglieroni
Jan 17, 2002·Journal of Neurosurgery·Matthias OertelNeil A Martin
Jan 1, 2003·Journal of Neurosurgery·Sherman C SteinDouglas H Smith
Sep 1, 2004·Journal of Clinical Neuroscience : Official Journal of the Neurosurgical Society of Australasia·Jinn-Rung KuoChung-Ching Chio
Sep 6, 2005·Journal of Critical Care·Venkatesh AiyagariMichael N Diringer
Sep 22, 2005·Neurocritical Care·Sherman C Stein, Douglas H Smith
Mar 23, 2007·Journal of Neurotrauma·Jackelien G M Van BeekAndrew I R Maas
Mar 23, 2007·Journal of Neurotrauma·Gordon D MurrayEwout W Steyerberg

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Citations

May 31, 2013·Critical Care : the Official Journal of the Critical Care Forum·Ariane GentileFrançois Sztark
Oct 10, 2018·Clinical and Applied Thrombosis/hemostasis : Official Journal of the International Academy of Clinical and Applied Thrombosis/Hemostasis·Chrysoula PapageorgiouGrigoris T Gerotziafas

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