Coagulation factor VIIa-mediated protease-activated receptor 2 activation leads to β-catenin accumulation via the AKT/GSK3β pathway and contributes to breast cancer progression.

The Journal of Biological Chemistry
Abhishek RoyProsenjit Sen

Abstract

Cell migration and invasion are very characteristic features of cancer cells that promote metastasis, which is one of the most common causes of mortality among cancer patients. Emerging evidence has shown that coagulation factors can directly mediate cancer-associated complications either by enhancing thrombus formation or by initiating various signaling events leading to metastatic cancer progression. It is well established that, apart from its distinct role in blood coagulation, coagulation factor FVIIa enhances aggressive behaviors of breast cancer cells, but the underlying signaling mechanisms still remain elusive. To this end, we investigated FVIIa's role in the migration and invasiveness of the breast cancer cell line MDA-MB-231. Consistent with previous observations, we observed that FVIIa increased the migratory and invasive potential of these cells. We also provide molecular evidence that protease-activated receptor 2 activation followed by PI3K-AKT activation and GSK3β inactivation is involved in these processes and that β-catenin, a well known tumor-regulatory protein, contributes to this signaling pathway. The pivotal role of β-catenin was further indicated by the up-regulation of its downstream targets cyclin D1, c...Continue Reading

References

Jun 25, 1996·Proceedings of the National Academy of Sciences of the United States of America·T H BuggeJ L Degen
Sep 5, 1996·Nature·P CarmelietD Collen
Apr 12, 2000·Proceedings of the National Academy of Sciences of the United States of America·S Y LinM C Hung
May 11, 2000·Proceedings of the National Academy of Sciences of the United States of America·E CamererS R Coughlin
Jun 1, 2002·Science·Randall T MoonNorbert Perrimon
Apr 23, 2004·Trends in Biochemical Sciences·Richard S Jope, Gail V W Johnson
Aug 10, 2004·Journal of Mammary Gland Biology and Neoplasia·Keith R Brennan, Anthony M C Brown
Jan 31, 2006·Journal of Cell Science·Ken M Cadigan, Yan I Liu
Feb 14, 2006·Modern Pathology : an Official Journal of the United States and Canadian Academy of Pathology, Inc·Lydia NakopoulouA Keramopoulos
May 5, 2006·Seminars in Thrombosis and Hemostasis·Wolfram Ruf, Barbara M Mueller
Sep 29, 2007·Blood·Henri H VersteegWolfram Ruf
Mar 15, 2008·Current Opinion in Cell Biology·He Huang, Xi He
Apr 1, 2008·Breast Cancer Research : BCR·Joanne E BluffCarolyn A Staton
Jul 23, 2008·Seminars in Thrombosis and Hemostasis·Florence Schaffner, Wolfram Ruf
Jul 24, 2008·Journal of Thrombosis and Haemostasis : JTH·H H VersteegM P Peppelenbosch
May 22, 2010·Journal of Mammary Gland Biology and Neoplasia·Douglas S MicalizziHeide L Ford
Jun 26, 2010·Circulation Research·Tata Purushothama Rao, Michael Kühl
Oct 19, 2011·Journal of Biomedicine & Biotechnology·Xinrui TianGuoping Zheng
Mar 1, 2012·Thrombosis and Haemostasis·Prosenjit SenL Vijaya Mohan Rao
Jun 15, 2012·Thrombosis Research·Jay L Degen, Joseph S Palumbo
Jun 12, 2012·Cell·Hans Clevers, Roel Nusse
Dec 22, 2012·Nature Reviews. Cancer·Jamie N Anastas, Randall T Moon
Jan 5, 2013·The Oncologist·Marion Cole, Michael Bromberg
Jul 17, 2013·Journal of Thrombosis and Haemostasis : JTH·B Kocatürk, H H Versteeg
Jul 31, 2013·Bioscience Reports·Luize G Lima, Robson Q Monteiro

❮ Previous
Next ❯

Citations

Jul 22, 2018·Journal of Thrombosis and Haemostasis : JTH·H ZelayaW Ruf
Jul 22, 2019·Molecular Neurobiology·Abuzer AliIbraheem Husain
Nov 30, 2018·Molecular Medicine Reports·Xinqiang SongYuan Luo
Mar 27, 2019·Multidisciplinary Respiratory Medicine·Martina SterclovaMartina Vasakova
Aug 28, 2021·International Journal of Molecular Sciences·Jeetendra Kumar NagRachel Bar-Shavit

❮ Previous
Next ❯

Related Concepts

Related Feeds

Cadherins and Catenins

Cadherins (named for "calcium-dependent adhesion") are a type of cell adhesion molecule (CAM) that is important in the formation of adherens junctions to bind cells with each other. Catenins are a family of proteins found in complexes with cadherin cell adhesion molecules of animal cells: alpha-catenin can bind to β-catenin and can also bind actin. β-catenin binds the cytoplasmic domain of some cadherins. Discover the latest research on cadherins and catenins here.

AKT Pathway

This feed focuses on the AKT serine/threonine kinase, which is an important signaling pathway involved in processes such as glucose metabolism and cell survival.

Adherens Junctions

An adherens junction is defined as a cell junction whose cytoplasmic face is linked to the actin cytoskeleton. They can appear as bands encircling the cell (zonula adherens) or as spots of attachment to the extracellular matrix (adhesion plaques). Adherens junctions uniquely disassemble in uterine epithelial cells to allow the blastocyst to penetrate between epithelial cells. Discover the latest research on adherens junctions here.

ASBMB Publications

The American Society for Biochemistry and Molecular Biology (ASBMB) includes the Journal of Biological Chemistry, Molecular & Cellular Proteomics, and the Journal of Lipid Research. Discover the latest research from ASBMB here.

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Blood Coagulation Signaling Pathways

Coagulation is the process by which a blood clot is formed. This process includes both the formation of a platelet plug as well as a cascade of clotting factors resulting in the formation of fibrin strands. Find the latest research on coagulation signaling pathways here.

Cell Migration

Cell migration is involved in a variety of physiological and pathological processes such as embryonic development, cancer metastasis, blood vessel formation and remoulding, tissue regeneration, immune surveillance and inflammation. Here is the latest research.

Cell Migration in Cancer and Metastasis

Migration of cancer cells into surrounding tissue and the vasculature is an initial step in tumor metastasis. Discover the latest research on cell migration in cancer and metastasis here.

Breast Invasive Carcinoma (Keystone)

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.

Breast Invasive Carcinoma

Invasive breast cancers indicate a spread into breast tissues and lymph nodes. Here are the latest discoveries pertaining to breast invasive carcinomas.