PMID: 5776551Mar 1, 1969Paper

Coagulation factors in chronic liver disease

Journal of Clinical Pathology
G W DonaldsonJ Richmond


Coagulation studies were carried out on 30 patients with chronic liver disease. The clotting defect was complex and involved factors V, VII, IX (Christmas factor), and prothrombin. Some patients showed a significant depression of factor IX in the presence of a normal one-stage prothrombin time. Thrombotest was found to be a good indicator of factor IX deficiency in this group of patients and may be of use as an additional liver function test. The screening of patients with liver disease for surgery or liver biopsy should assess the coagulation factors involved in both intrinsic and extrinsic thromboplastin generation.


Feb 1, 1953·Journal of Clinical Pathology·R BIGGS, A S DOUGLAS
Nov 1, 1956·Journal of Clinical Pathology·D C COWLING
Feb 1, 1959·The American Journal of Medicine·R B FINKBINERJ P BUNKER
Sep 7, 1963·Lancet·P KIDDR BIGGS
Jan 1, 1965·Anaesthesia·R WILLIAMS
Aug 11, 1960·The New England Journal of Medicine·S I RAPAPORTJ R GOODMAN


Aug 1, 1975·The American Journal of Digestive Diseases·R L BickE Shanbrom
Nov 19, 1981·The New England Journal of Medicine·D L Earnest, J J Corrigan
Nov 1, 1976·British Journal of Haematology·G GreenL Poller
Jul 5, 1969·British Medical Journal·P T FluteR Y Calne
May 1, 1970·Journal of Clinical Pathology·P M Mannucci
Nov 1, 1976·Journal of Clinical Pathology·G GreenI W Dymock
Dec 24, 2015·Current Medical Research and Opinion·Timothy H SelfAmanda Howard-Thompson
Aug 12, 2009·Clinics in Laboratory Medicine·Valerie L Ng
Dec 2, 2008·Pediatric Clinics of North America·Arthur N FeinbergOrhan K Atay
Dec 25, 2015·Saudi Pharmaceutical Journal : SPJ : the Official Publication of the Saudi Pharmaceutical Society·Mahmoud I Abdel-AzizTahani H Elfaham
Jan 1, 1982·American Journal of Surgery·G V AranhaH B Greenlee
Jan 1, 1994·Computers in Biology and Medicine·T W Chung, E A O'Rear
Jan 1, 1993·Journal of Neural Transmission. Parkinson's Disease and Dementia Section·H BaasP A Fischer
Jan 1, 1970·Psychopharmacologia·I P Stolerman, R Kumar
Dec 1, 1970·Gut·S G Elkington
Sep 12, 2018·The Western Journal of Emergency Medicine·Michael F Harrison
Nov 1, 1980·Scandinavian Journal of Haematology·R LandolfiB Bizzi
Jul 1, 1982·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·H A LiebmanB Furie
Mar 29, 2021·Journal of Thrombosis and Haemostasis : JTH·Dafna J GroeneveldJames P Luyendyk

Related Concepts

Blood Coagulation Disorders
Factor IX
Factor V
Factor VII
Liver Dysfunction
Liver Function Tests

Related Feeds

Blood Clotting Disorders

Thrombophilia includes conditions with increased tendency for excessive blood clotting. Blood clotting occurs when the body has insufficient amounts of specialized proteins that make blood clot and stop bleeding. Here is the latest research on blood clotting disorders.

Related Papers

The New England Journal of Medicine
European Heart Journal
Martin Moser, Christoph Bode
© 2021 Meta ULC. All rights reserved