Coagulation management in massive bleeding

Current Opinion in Anaesthesiology
Matthew J GriffeePer A Thorborg

Abstract

To update readers on recent literature regarding treatment of coagulopathy for patients with life-threatening bleeding, highlighting emerging therapeutic options, controversial topics, and ongoing clinical trials. Massive transfusion protocols featuring immediate availability of blood products and multidisciplinary communication reduce mortality and conserve resources. There is a growing consensus that immediate administration of plasma and platelet units in a 1: 1: 1 ratio with red cell units reduces early mortality. Lyophilized and recombinant blood product components may have advantages over traditional blood products in certain clinical circumstances. Massive transfusion protocols standardize treatment of the coagulopathy of massive bleeding, leading to rapid restoration of hemostasis and decrease in early mortality.

References

Mar 21, 2000·The European Journal of Surgery = Acta Chirurgica·R J Goris
Jun 19, 2003·The Journal of Trauma·Karim BrohiTimothy Coats
Apr 28, 2007·Journal of Thrombosis and Haemostasis : JTH·C Velik-SalchnerD Fries
May 15, 2007·The Journal of Trauma·Jeremy G PerkinsJohn B Holcomb
Feb 23, 2008·Anesthesia and Analgesia·Thorsten HaasPetra Innerhofer
May 13, 2008·The Journal of Trauma·Karim BrohiJean-François Pittet
Jul 5, 2008·Transfusion Medicine·R Weinkove, S Rangarajan
Jul 23, 2008·Archives of Surgery·Terence O'KeeffeRavi Sarode
Feb 11, 2009·The Journal of Trauma·Christopher W SnyderJeffrey D Kerby
May 23, 2009·BJOG : an International Journal of Obstetrics and Gynaecology·C HuissoudR-C Rudigoz
Jun 3, 2009·Critical Care : the Official Journal of the Critical Care Forum·Bernard Vigué
Jul 28, 2009·Journal of the American College of Surgeons·Daniel J RiskinSusan I Brundage
Aug 12, 2009·The Journal of Trauma·Gregory A WatsonUNKNOWN Inflammation and Host Response to Injury Investigators
Sep 10, 2009·Clinical Trials : Journal of the Society for Clinical Trials·Richard DuttonUNKNOWN CONTROL Steering Committee
Sep 25, 2009·Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine·Pär I JohanssonSisse R Ostrowski
Oct 9, 2009·Current Opinion in Critical Care·Rob Dawes, G O Rhys Thomas
Oct 10, 2009·Der Anaesthesist·H LierH Schöchl
Oct 13, 2009·The Journal of Trauma·Hasan B AlamUNKNOWN Hemostatic Resuscitation Research Group

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Citations

Aug 1, 2011·European Journal of Trauma and Emergency Surgery : Official Publication of the European Trauma Society·Yusuf Alper KılıçVolkan Kaynaroğlu
Feb 5, 2014·Anesthesiology Clinics·Mary C Theroux, Sabina DiCindio
Jul 13, 2011·Journal of Intensive Care Medicine·Gordon M Riha, Martin A Schreiber
Nov 22, 2013·Gut Microbes·Deng Pan, Zhongtang Yu

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