Coagulation studies as a prognostic index in acute liver failure

British Journal of Haematology
I W DymockJ M Thomson

Abstract

A coagulation screen has been performed on 12 patients with acute liver failure. Six died and six recovered. All six fatal cases developed a haemorrhagic state with haemostatic failure. An attempt has been made to delineate the various mechanisms for the production of the coagulation defect. The significance of the different haematological parameters in assessing prognosis has been assessed. The study emphasizes the importance of the synthetic ability of the liver in determining survival prospects. A good correlation between the factor-VII level, which is a guide to liver synthesis, and recovery has been shown. The value of a specific factor-VII assay in acute liver failure appears considerable. Where this assay cannot be performed the clot opacity fibrinogen technique provides a reasonable guide to the prognosis. The presence or absence of DIC was not a determinant factor in survival in this series.

References

Mar 14, 1970·Lancet·M O RakeR Williams
Jan 1, 1968·Acta Haematologica·G TytgatM Verstraete
Dec 1, 1972·Journal of Clinical Pathology·L Poller, J M Thomson
Aug 1, 1971·The Journal of Clinical Investigation·G N TytgatM Verstraete
Mar 1, 1970·American Journal of Clinical Pathology·S ZuckerE C Hall
May 1, 1970·Journal of Clinical Pathology·M R AldersonJ M Thomson
Apr 1, 1971·American Journal of Clinical Pathology·D E LeavelleC A Owen
Jul 1, 1969·Proceedings of the Society for Experimental Biology and Medicine·C MerskeyA J Johnson
Nov 1, 1960·Journal of Clinical Pathology·G I INGRAM, M O MATCHETT

❮ Previous
Next ❯

Citations

Jan 1, 1985·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·B CornillonR Eloy
Dec 25, 2002·Journal of Pediatric Gastroenterology and Nutrition·Sylvie LebelKatryn N Furuya
Jul 1, 1990·Journal of Gastroenterology and Hepatology·N Tygstrup
Oct 27, 1990·BMJ : British Medical Journal·P M HarrisonR Williams
Mar 1, 1986·Gut·D A Kelly, E G Tuddenham
Nov 1, 1976·Journal of Clinical Pathology·G GreenI W Dymock
Mar 1, 1988·Journal of Clinical Pathology·T TakaseA H Goodall
Oct 15, 1998·Journal of Clinical Pathology·A S LawrieS J Machin
Jan 1, 1995·Annual Review of Medicine·E Atillasoy, P D Berk
May 12, 2007·Pediatric Transplantation·Thomas HeffronRene Romero
Jul 23, 2008·Pediatric Transplantation·David A RudnickUNKNOWN Pediatric Acute Liver Failure Study Group
Apr 18, 2012·Alimentary Pharmacology & Therapeutics·K A WlodzimirowR A F M Chamuleau
May 1, 1981·Thrombosis Research·E HillerK Possinger
Jan 1, 1988·The Veterinary Clinics of North America. Small Animal Practice·R A Green
Dec 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J R PernambucoR Williams
Jul 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F VioliC Cordova
Jan 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A L BoksH H Van Vliet
Jan 1, 1982·Alcoholism, Clinical and Experimental Research·M V RagniU Hasiba
Nov 30, 1987·Genetica·R A Van den BusscheK T Scribner
Oct 19, 2012·European Journal of Gastroenterology & Hepatology·Maria MagnussonAntal Németh
Jul 1, 1995·Revista Da Sociedade Brasileira De Medicina Tropical·J J da SilvaA V de Oliveira
May 8, 2002·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·F SobasC Négrier
Nov 7, 2019·Journal of Gastroenterology and Hepatology·Stephen WarrillowRinaldo Bellomo
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·R KerrC A Ludlam
Jan 1, 1982·Clinical and Laboratory Haematology·F RuizA V Swan
May 8, 2020·Diagnostics·Alina GramaTudor Lucian Pop
Jan 5, 2007·World Journal of Gastroenterology : WJG·M SenzoloA-K Burroughs

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.