Coagulation studies as a prognostic index in acute liver failure

British Journal of Haematology
I W DymockJ M Thomson

Abstract

A coagulation screen has been performed on 12 patients with acute liver failure. Six died and six recovered. All six fatal cases developed a haemorrhagic state with haemostatic failure. An attempt has been made to delineate the various mechanisms for the production of the coagulation defect. The significance of the different haematological parameters in assessing prognosis has been assessed. The study emphasizes the importance of the synthetic ability of the liver in determining survival prospects. A good correlation between the factor-VII level, which is a guide to liver synthesis, and recovery has been shown. The value of a specific factor-VII assay in acute liver failure appears considerable. Where this assay cannot be performed the clot opacity fibrinogen technique provides a reasonable guide to the prognosis. The presence or absence of DIC was not a determinant factor in survival in this series.

References

Mar 14, 1970·Lancet·M O RakeR Williams
Jan 1, 1968·Acta Haematologica·G TytgatM Verstraete
Dec 1, 1972·Journal of Clinical Pathology·L Poller, J M Thomson
Aug 1, 1971·The Journal of Clinical Investigation·G N TytgatM Verstraete
Mar 1, 1970·American Journal of Clinical Pathology·S ZuckerE C Hall
May 1, 1970·Journal of Clinical Pathology·M R AldersonJ M Thomson
Apr 1, 1971·American Journal of Clinical Pathology·D E LeavelleC A Owen
Jul 1, 1969·Proceedings of the Society for Experimental Biology and Medicine·C MerskeyA J Johnson
Nov 1, 1960·Journal of Clinical Pathology·G I Ingram, M O MATCHETT

Citations

Jan 1, 1985·Comparative Biochemistry and Physiology. C, Comparative Pharmacology and Toxicology·B CornillonR Eloy
Dec 25, 2002·Journal of Pediatric Gastroenterology and Nutrition·Sylvie LebelKatryn N Furuya
Jul 1, 1990·Journal of Gastroenterology and Hepatology·N Tygstrup
Oct 27, 1990·BMJ : British Medical Journal·P M HarrisonR Williams
Mar 1, 1986·Gut·D A Kelly, E G Tuddenham
Nov 1, 1976·Journal of Clinical Pathology·G GreenI W Dymock
Mar 1, 1988·Journal of Clinical Pathology·T TakaseA H Goodall
Oct 15, 1998·Journal of Clinical Pathology·A S LawrieS J Machin
Jan 1, 1995·Annual Review of Medicine·E Atillasoy, P D Berk
Feb 1, 1989·Mayo Clinic Proceedings·D M RitterR A Krom
May 12, 2007·Pediatric Transplantation·Thomas HeffronRene Romero
Jul 23, 2008·Pediatric Transplantation·David A RudnickPediatric Acute Liver Failure Study Group
Apr 18, 2012·Alimentary Pharmacology & Therapeutics·K A WlodzimirowR A F M Chamuleau
May 1, 1981·Thrombosis Research·E HillerK Possinger
Jan 1, 1988·The Veterinary Clinics of North America. Small Animal Practice·R A Green
Dec 1, 1993·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·J R PernambucoR Williams
Jul 1, 1995·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·F VioliC Cordova
Jan 1, 1986·Hepatology : Official Journal of the American Association for the Study of Liver Diseases·A L BoksH H Van Vliet
Jan 1, 1982·Alcoholism, Clinical and Experimental Research·M V RagniU Hasiba
Nov 30, 1987·Genetica·R A Van den BusscheK T Scribner
Oct 19, 2012·European Journal of Gastroenterology & Hepatology·Maria MagnussonAntal Németh
Jul 1, 1995·Revista Da Sociedade Brasileira De Medicina Tropical·J J da SilvaA V de Oliveira
May 8, 2002·Blood Coagulation & Fibrinolysis : an International Journal in Haemostasis and Thrombosis·F SobasC Négrier
Nov 7, 2019·Journal of Gastroenterology and Hepatology·Stephen WarrillowRinaldo Bellomo
Jul 23, 2003·Journal of Thrombosis and Haemostasis : JTH·R KerrC A Ludlam
Jan 1, 1982·Clinical and Laboratory Haematology·F RuizA V Swan
May 8, 2020·Diagnostics·Alina GramaTudor Lucian Pop
Jan 5, 2007·World Journal of Gastroenterology : WJG·M SenzoloA-K Burroughs

Related Concepts

Teens
Complete Blood Count
Blood Coagulation Tests
Blood Platelets
Factor V
Factor VII
Fibrin split products
Gamma-Fibrinogen
Liver Dysfunction
Phosphatidylethanolamines

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Lipidomics & Rhinovirus Infection

Lipidomics can be used to examine the lipid species involved with pathogenic conditions, such as viral associated inflammation. Discovered the latest research on Lipidomics & Rhinovirus Infection.

Spatio-Temporal Regulation of DNA Repair

DNA repair is a complex process regulated by several different classes of enzymes, including ligases, endonucleases, and polymerases. This feed focuses on the spatial and temporal regulation that accompanies DNA damage signaling and repair enzymes and processes.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Torsion Dystonia

Torsion dystonia is a movement disorder characterized by loss of control of voluntary movements appearing as sustained muscle contractions and/or abnormal postures. Here is the latest research.

Archaeal RNA Polymerase

Archaeal RNA polymerases are most similar to eukaryotic RNA polymerase II but require the support of only two archaeal general transcription factors, TBP (TATA-box binding protein) and TFB (archaeal homologue of the eukaryotic general transcription factor TFIIB) to initiate basal transcription. Here is the latest research on archaeal RNA polymerases.

Alzheimer's Disease: MS4A

Variants within the membrane-spanning 4-domains subfamily A (MS4A) gene cluster have recently been implicated in Alzheimer's disease in genome-wide association studies. Here is the latest research on Alzheimer's disease and MS4A.

Central Pontine Myelinolysis

Central Pontine Myelinolysis is a neurologic disorder caused most frequently by rapid correction of hyponatremia and is characterized by demyelination that affects the central portion of the base of the pons. Here is the latest research on this disease.