Coagulopathies Are a Risk Factor for Adverse Events Following Total Hip and Total Knee Arthroplasty

Orthopedics
Rohil MalpaniJonathan N Grauer

Abstract

Current literature suggests a correlation between preoperative coagulopathies and postsurgical adverse events (AEs). However, this correlation has not been specifically assessed in the total hip arthroplasty (THA) and the total knee arthroplasty (TKA) populations. Patients who underwent primary THA and TKA with coagulopathy data were identified from the 2011-2015 American College of Surgeons National Surgical Quality Improvement Program database. Coagulopathies studied were low platelets, high partial thromboplastin time (PTT), high international normalized ratio (INR), and other hematological conditions. Univariate and multivariate analyses were conducted to explore the relationship between coagulopathies and 30-day AEs following surgery in these populations. In total, 39,605 THA patients and 67,685 TKA patients were identified. Of these, approximately 16% had a coagulopathy. These patients tended to be older and have a dependent functional status, American Society of Anesthesiologists score of 3 or greater, and diabetes mellitus. In the THA cohort, low platelets, high PTT, high INR, and other hematological conditions were associated with increased odds of any AE, major AEs, and minor AEs. High INR and other hematological cond...Continue Reading

References

Nov 1, 1988·Annals of Surgery·M J RohrerD L Nahrwold
Feb 11, 1999·The Journal of Bone and Joint Surgery. American Volume·B E BierbaumR B Welch
Sep 1, 2005·Transfusion·Jodi B SegalUNKNOWN Transfusion Medicine/Hemostasis Clinical Trials Network
Apr 11, 2009·Clinical Orthopaedics and Related Research·Steven M KurtzKevin J Bozic
Sep 27, 2012·JAMA : the Journal of the American Medical Association·Peter CramBrian R Wolf
Aug 2, 2013·Anesthesiology·Laurent G GlanceAndrew W Dick
Aug 16, 2013·Current Opinion in Hematology·Lauren Hogshire, Jeffrey L Carson
Apr 8, 2014·Clinical Orthopaedics and Related Research·Cesar S MolinaManish K Sethi
Jun 29, 2014·The Journal of Arthroplasty·Philip J BelmontAndrew J Schoenfeld
Dec 5, 2014·The Journal of Bone and Joint Surgery. American Volume·Adam HartJohn Antoniou
Jul 29, 2015·JAMA : the Journal of the American Medical Association·Andrew S BoozaryRoger F Wicker
Sep 15, 2016·The Journal of Arthroplasty·Joshua W HustedtMark J Spangehl
Feb 27, 2017·The Journal of Arthroplasty·Patawut BovonratwetJonathan N Grauer
Jun 13, 2017·The Journal of Arthroplasty·Joseph E TanenbaumRandall E Marcus
Nov 1, 2017·The Journal of Bone and Joint Surgery. American Volume·Brianna L SiracuseKathleen S Beebe

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Citations

Aug 25, 2021·The Journal of Arthroplasty·Christopher WesterMohamad J Halawi

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