Coalescent tree imbalance and a simple test for selective sweeps based on microsatellite variation

PLoS Computational Biology
Haipeng Li, Thomas Wiehe

Abstract

Selective sweeps are at the core of adaptive evolution. We study how the shape of coalescent trees is affected by recent selective sweeps. To do so we define a coarse-grained measure of tree topology. This measure has appealing analytical properties, its distribution is derived from a uniform, and it is easy to estimate from experimental data. We show how it can be cast into a test for recent selective sweeps using microsatellite markers and present an application to an experimental data set from Plasmodium falciparum.

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Citations

Nov 21, 2015·Nucleic Acids Research·Gilad LibermanYoram Louzoun
Jun 21, 2015·Molecular Biology and Evolution·Haley Hunter-Zinck, Andrew G Clark
Jul 22, 2015·Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences·Connor O McCoyFrederick A Matsen
Sep 3, 2013·Mathematical Biosciences·Filippo DisantoThomas Wiehe
Jul 7, 2017·Genetics·Luca FerrettiSebastian E Ramos-Onsins
Nov 12, 2019·PLoS Computational Biology·Yichen Zheng, Thomas Wiehe
May 5, 2016·PLoS Computational Biology·Jerome KelleherGilean McVean
Jul 23, 2019·Theoretical Population Biology·Johannes Wirtz, Thomas Wiehe
Nov 4, 2020·Proceedings of the National Academy of Sciences of the United States of America·Jaehee KimJulia A Palacios

Related Concepts

In Silico
Genetics, Population
Plasmodium falciparum
Variation (Genetics)
Tetranucleotide Repeats
Computational Molecular Biology
Online Mendelian Inheritance In Man
Anatomy, Regional
Biological Evolution
Trees (plant)

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