Coartem(®): a decade of patient-centric malaria management

Expert Review of Anti-infective Therapy
Kamal Hamed, Heiner Grueninger

Abstract

The adoption of artemisinin-based combination therapy, together with other malaria control strategies, has played a significant role in reducing the burden of malaria in many endemic countries. The artemisinin-based combination therapy artemether-lumefantrine (AL; Coartem(®), Novartis Pharma AG, Basel, Switzerland) has demonstrated consistently high efficacy and safety for over a decade. Currently deployed as a first- or second-line treatment in most sub-Saharan African countries, its extensive use is endorsed by a lack of reported parasite resistance in Africa to date. With a focus on patient needs, AL offers a tailored formulation for infants and children, and packaging solutions to promote adherence. Working towards malaria elimination, innovative strategies using AL, such as treatment of asymptomatic carriers, will be of interest. AL has the potential to continue playing an important role in saving lives.

References

Jul 14, 1999·The American Journal of Tropical Medicine and Hygiene·M V VugtS Looareesuwan
Aug 24, 1999·European Journal of Clinical Pharmacology·M A van AgtmaelC J van Boxtel
Feb 19, 2000·Antimicrobial Agents and Chemotherapy·F EzzetN J White
Mar 23, 2000·European Journal of Pharmaceutical Sciences : Official Journal of the European Federation for Pharmaceutical Sciences·G LefèvreM S Thomsen
Nov 15, 2000·Lancet·A KanekoA Björkman
Jan 2, 2001·Transactions of the Royal Society of Tropical Medicine and Hygiene·M van VugtF Nosten
Oct 5, 2002·Journal of Clinical Pharmacology·Gilbert LefèvreDereck Amakye
Oct 2, 2003·Trends in Parasitology·Lorenz von Seidlein, Brian M Greenwood
Apr 28, 2004·Transactions of the Royal Society of Tropical Medicine and Hygiene·Stephen Toovey, Andrew Jamieson
Jul 15, 2004·Transactions of the Royal Society of Tropical Medicine and Hygiene·Ishag AdamMustafa Idris Elbashir
Oct 30, 2004·Journal of Obstetrics and Gynaecology : the Journal of the Institute of Obstetrics and Gynaecology·A SowunmiA O Arowojolu
Apr 20, 2005·Transactions of the Royal Society of Tropical Medicine and Hygiene·Catherine FaladePatricia Ibarra de Palacios
Nov 24, 2005·Antimicrobial Agents and Chemotherapy·Joel TarningNicholas J White
Oct 3, 2006·PLoS Clinical Trials·Samuel DunyoMargaret Pinder
Oct 21, 2006·European Journal of Clinical Pharmacology·Rose McGreadyFrançois Nosten
Dec 14, 2006·Expert Opinion on Pharmacotherapy·Gilbert KokwaroAlexis Nzila
Dec 21, 2006·Tropical Medicine & International Health : TM & IH·Mey Bouth DenisPascal Ringwald
Feb 16, 2007·Tropical Medicine & International Health : TM & IH·Elizabeth A AshleyFrançois Nosten
Feb 16, 2007·Malaria Journal·Stephanie DellicourBrian Greenwood
Jun 16, 2007·The Korean Journal of Parasitology·Srivicha KrudsoodSornchai Looareesuwan
Feb 27, 2008·Antimicrobial Agents and Chemotherapy·K Stepniewska, N J White
Dec 10, 2008·The New England Journal of Medicine·Harin A KarunajeewaTimothy M E Davis
Apr 4, 2009·Annals of Tropical Medicine and Parasitology·I AdamG K Adam
May 30, 2009·The Journal of Infectious Diseases·Frederick N BaliraineGuiyun Yan
Jun 10, 2009·Journal of Acquired Immune Deficiency Syndromes : JAIDS·Polina GermanFrancesca T Aweeka

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Citations

Aug 12, 2014·Expert Opinion on Pharmacotherapy·Benjamin J VisserMartin P Grobusch
May 10, 2013·Expert Review of Clinical Pharmacology·Kesara Na-Bangchang, Juntra Karbwang
May 28, 2015·Antimicrobial Agents and Chemotherapy·Quique BassatKamal Hamed

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