Coassembly of different sulfonylurea receptor subtypes extends the phenotypic diversity of ATP-sensitive potassium (KATP) channels.

Molecular Pharmacology
Adam WheelerKim W Chan

Abstract

K(ATP) channels are metabolic sensors and targets of potassium channel openers (KCO; e.g., diazoxide and pinacidil). They comprise four sulfonylurea receptors (SUR) and four potassium channel subunits (Kir6) and are critical in regulating insulin secretion. Different SUR subtypes (SUR1, SUR2A, SUR2B) largely determine the metabolic sensitivities and the pharmacological profiles of K(ATP) channels. SUR1- but not SUR2-containing channels are highly sensitive to metabolic inhibition and diazoxide, whereas SUR2 channels are sensitive to pinacidil. It is generally believed that SUR1 and SUR2 are incompatible in channel coassembly. We used triple tandems, T1 and T2, each containing one SUR (SUR1 or SUR2A) and two Kir6.2Delta26 (last 26 residues are deleted) to examine the coassembly of different SUR. When T1 or T2 was expressed in Xenopus laevis oocytes, small whole-cell currents were activated by metabolic inhibition (induced by azide) plus a KCO (diazoxide for T1, pinacidil for T2). When coexpressed with any SUR subtype, the activated-currents were increased by 2- to 13-fold, indicating that different SUR can coassemble. Consistent with this, heteromeric SUR1+SUR2A channels were sensitive to azide, diazoxide, and pinacidil, and the...Continue Reading

References

May 1, 1997·Neuron·J P ClementJ Bryan
Jan 10, 1998·The Journal of General Physiology·S Shyng, C G Nichols
Apr 16, 1999·Endocrine Reviews·L Aguilar-Bryan, J Bryan
Oct 16, 1999·Circulation Research·A BaronA J Baertschi
Aug 25, 2000·The Journal of Biological Chemistry·A P BabenkoJ Bryan
Jan 3, 2001·Proceedings of the National Academy of Sciences of the United States of America·Y CuiA Tinker
Jul 13, 2001·Journal of Molecular and Cellular Cardiology·D J PountneyW A Coetzee
Feb 5, 2002·The Journal of Biological Chemistry·Jonathan P GiblinAndrew Tinker
Aug 30, 2002·Journal of Pediatric Endocrinology & Metabolism : JPEM·Feyza DarendelilerHülya Günöz
Sep 25, 2002·Proceedings of the National Academy of Sciences of the United States of America·Leonid V ZingmanAndre Terzic
Jun 24, 2003·Diabetologia·F M Gribble, F Reimann
Aug 28, 2003·The Journal of Biological Chemistry·Andrey P Babenko, Joseph Bryan
May 17, 2005·Journal of Molecular and Cellular Cardiology·Ricard MasiaColin G Nichols
May 25, 2005·Journal of Molecular and Cellular Cardiology·Katsuya Yamada, Nobuya Inagaki
May 25, 2005·Journal of Molecular and Cellular Cardiology·Christophe MoreauMichel Vivaudou
Jun 15, 2005·Journal of Molecular and Cellular Cardiology·A Jahangir, Andre Terzic
Jun 28, 2005·Journal of Molecular and Cellular Cardiology·Nian-Qing ShiJonathan C Makielski
Jun 28, 2005·Journal of Molecular and Cellular Cardiology·Andrey P Babenko
Aug 3, 2005·The Journal of Clinical Investigation·Frances M Ashcroft
Jan 19, 2006·Proceedings of the National Academy of Sciences of the United States of America·Domenico TricaricoDiana Conte Camerino

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Citations

Jul 9, 2010·The Journal of Biological Chemistry·Jingdong LiPeter J Mohler
Jul 29, 2010·Physiological Reviews·Thomas P FlaggColin G Nichols
Nov 8, 2011·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Hector Barajas-MartínezCharles Antzelevitch
Jul 18, 2009·Journal of Molecular and Cellular Cardiology·Haixia ZhangColin G Nichols
Jul 12, 2013·Oxidative Medicine and Cellular Longevity·Manuel J RodríguezNicole Mahy
Dec 2, 2011·Journal of Biomedicine & Biotechnology·Monika I HollenhorstMartin Fronius
Aug 26, 2010·Heart Rhythm : the Official Journal of the Heart Rhythm Society·Charles Antzelevitch, Hector Barajas-Martinez
Jan 23, 2015·Evidence-based Complementary and Alternative Medicine : ECAM·Xiao-Gang GongLing Ma
Jun 1, 2016·Frontiers in Pharmacology·Paola ImbriciDiana Conte
May 11, 2016·Future Medicinal Chemistry·Sujay V KharadeJerod S Denton
Mar 30, 2013·Circulation Research·Colin G NicholsDorothy K Grange
Apr 3, 2014·Physiological Reviews·Ildiko Szabo, Mario Zoratti
Sep 21, 2013·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Katrin RichterMartin Fronius
May 28, 2019·Hypertension·Conor McClenaghanColin G Nichols
Apr 8, 2017·Royal Society Open Science·Christopher H EmfingerColin G Nichols
Oct 20, 2012·Biochemistry·Jorge P López-AlonsoVoula Kanelis

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