Coat colour in dogs: identification of the merle locus in the Australian shepherd breed

BMC Veterinary Research
Benoit HédanCatherine André

Abstract

Coat colours in canines have many natural phenotypic variants. Some of the genes and alleles involved also cause genetic developmental defects, which are also observed in humans and mice. We studied the genetic bases of the merle phenotype in dogs to shed light on the pigmentation mechanisms and to identify genes involved in these complex pathways. The merle phenotype includes a lack of eumelanic pigmentation and developmental defects, hearing impairments and microphthalmia. It is similar to that observed in microphthalmia mouse mutants. Taking advantage of the dog as a powerful genetic model and using recently available genomic resources, we investigated the segregation of the merle phenotype in a five-generation pedigree, comprising 96 sampled Australian shepherd dogs. Genetic linkage analysis allowed us to identify a locus for the merle phenotype, spanning 5.5 megabases, at the centromeric tip of canine chromosome 10 (CFA10). This locus was supported by a Lod score of 15.65 at a recombination fraction theta = 0. Linkage analysis in three other breeds revealed that the same region is linked to the merle phenotype. This region, which is orthologous to human chromosome 12 (HSA12 q13-q14), belongs to a conserved ordered segment ...Continue Reading

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Citations

Dec 15, 2015·Frontiers in Veterinary Science·George M Strain
Jan 1, 2013·Annual Review of Animal Biosciences·Christopher B Kaelin, Gregory S Barsh
Mar 1, 2008·Comparative Biochemistry and Physiology. Part D, Genomics & Proteomics·Francis Galibert, Catherine André
Sep 21, 2018·PloS One·Mary LangevinSona Pekova
Sep 21, 2011·Veterinary Ophthalmology·András M KomáromyBrendan G Mangan
Sep 9, 2018·Scientific Reports·Céline Le BéguecChristophe Hitte
Jun 27, 2019·Acta Veterinaria Hungarica·Zsófia PellesPetra Zenke
Nov 10, 2021·Animal Genetics·L BrancalionC M Wade

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Methods Mentioned

BETA
genotyping
PCR
column filtration

Software Mentioned

CRI
MAP
GeneMapper
GLUE
MultiMap
Cyrillic
Cyrillic2
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