Coat proteins and vesicle budding

Science
R Schekman, L Orci

Abstract

The trafficking of proteins within eukaryotic cells is achieved by the capture of cargo and targeting molecules into vesicles that bud from a donor membrane and deliver their contents to a receiving department. This process is bidirectional and may involve multiple organelles within a cell. Distinct coat proteins mediate each budding event, serving both to shape the transport vesicle and to select by direct or indirect interaction the desired set of cargo molecules. Secretion, which has been viewed as a default pathway, may require sorting and packaging signals on transported molecules to ensure their rapid delivery to the cell surface.

References

Dec 1, 1992·The Journal of Cell Biology·E SmytheS L Schmid
Jan 1, 1992·Proceedings of the National Academy of Sciences of the United States of America·J L CarpentierL Orci
Feb 21, 1992·Cell·K G RothbergR G Anderson
Sep 1, 1991·The Journal of Cell Biology·S L Schmid, E Smythe
Oct 1, 1991·Proceedings of the National Academy of Sciences of the United States of America·L OrciR Schekman
Feb 7, 1991·Nature·R Lipowsky
Feb 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·T StearnsR A Kahn
Oct 1, 1990·Proceedings of the National Academy of Sciences of the United States of America·J L Dul, Y Argon
Jan 1, 1990·Annual Review of Cell Biology·B M Pearse, M S Robinson
Aug 1, 1990·The Journal of Cell Biology·N Dean, H R Pelham
Jan 1, 1989·Annual Review of Cell Biology·H R Pelham
Nov 29, 1985·Science·G S Payne, R Schekman
Aug 1, 1986·Journal of Microscopy·K T Tokuyasu
Nov 1, 1974·Proceedings of the National Academy of Sciences of the United States of America·M P Sheetz, S J Singer
Jan 24, 1973·Molecular & General Genetics : MGG·T A GrigliattiD T Suzuki
Nov 2, 1995·Nature·P ScheiffeleK Simons
Aug 1, 1995·Current Opinion in Cell Biology·H R Pelham

❮ Previous
Next ❯

Citations

Sep 12, 1998·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·N T Ktistakis
Feb 23, 2000·BioEssays : News and Reviews in Molecular, Cellular and Developmental Biology·T E TjelleT Berg
Feb 13, 2001·Microscopy Research and Technique·J Vorísek
May 18, 2000·Biochemical and Biophysical Research Communications·H TakatsuK Nakayama
Aug 1, 1996·Trends in Cell Biology·M Aridor, W E Balch
Dec 1, 1996·Trends in Cell Biology·S Y BednarekR Schekman
Sep 24, 2013·Trends in Biochemical Sciences·Jure DergancAlenka Copič
May 22, 2003·Progress in Biophysics and Molecular Biology·Catherine van VlietPaul A Gleeson
Nov 26, 1998·Progress in Lipid Research·J E ThompsonY Hong
Apr 21, 1999·Progress in Lipid Research·P MoreauC Cassagne
Aug 28, 2001·Molecular and Biochemical Parasitology·Y Saito-NakanoT Nozaki
Jun 6, 2000·Advanced Drug Delivery Reviews·C T Okamoto
Nov 9, 2000·Archives of Medical Research·Y Saito-NakanoT Nozaki
Apr 9, 1998·Peptides·G E Feurle
Nov 19, 1997·Progress in Neurobiology·A F Rocha
Dec 2, 1999·Biochimica Et Biophysica Acta·K YamashitaT Ohkura
Jun 30, 2000·Current Opinion in Cell Biology·B S Glick
Jul 17, 2001·Current Opinion in Cell Biology·B Antonny, R Schekman
Jul 17, 2001·Current Opinion in Cell Biology·W B Huttner, J Zimmerberg
Oct 18, 2002·Current Opinion in Cell Biology·Charles Barlowe
Aug 1, 1996·Current Opinion in Cell Biology·M N SeamanS D Emr
Aug 1, 1997·Current Opinion in Cell Biology·M J Kuehn, R Schekman
Aug 1, 1997·Current Opinion in Cell Biology·P Cosson, F Letourneur
Jun 14, 2000·Current Opinion in Neurobiology·A T Brunger
Apr 12, 2001·Current Opinion in Structural Biology·A T Brunger
Apr 30, 2002·Trends in Cell Biology·Wieland B Huttner, Anne A Schmidt
Jun 7, 2003·Trends in Cell Biology·Charles Barlowe
Feb 1, 1997·Trends in Cell Biology·I C Marshall, K L Wilson
Mar 1, 1997·Trends in Cell Biology·M S Robinson
Aug 8, 1998·Trends in Cell Biology·S I BannykhW E Balch
Aug 8, 1998·Trends in Cell Biology·M G Farquhar, G E Palade
Aug 8, 1998·Trends in Cell Biology·J Lippincott-SchwartzJ Presley
Aug 26, 1998·Trends in Cell Biology·G OdorizziS D Emr

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.