PMID: 2484455Dec 1, 1989Paper

Coated fibronectin induces adhesion in the human monocytic cell line U937

Journal of Clinical & Laboratory Immunology
K SuzukiH Nakamura

Abstract

The differentiation inducing effect of coated human fibronectin (HFN) on U937 was investigated. U937 cells usually proliferate without stimuli. HFN induced the adhesion of about 20% of U937 cells in a serum free medium. HFN did not inhibit cell growth nor induce CD14 expression. The adhesion inducing activity of HFN was completely blocked by addition of anti-HFN antibody. Phorbor 12-myristate 13-acetate (PMA), another differentiation inducing agent, inhibited the growth of U937 cells but did not induce adhesion in the serum free medium. These data imply that HFN has a differentiation inducing effect on a human monocytic cell line and could be used as a biological response modifier.

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