Coating and Pharmacokinetic Evaluation of Air Spray Coated Drug Coated Balloons

Cardiovascular Engineering and Technology
Emily A TurnerSaami K Yazdani

Abstract

Drug coated balloons (DCB) are becoming the standard-care treatment for peripheral arterial disease (PAD). DCB use excipients to transfer and retain anti-proliferative drugs, such as paclitaxel. Excipients thus play a vital role in the design and function of DCB, however methods to coat balloons with excipients and anti-proliferative drugs remain unknown. The goal of this study was to thus develop an approach to coat and evaluate DCB for various excipients. An air sprayer method was developed to deposit paclitaxel and various excipients onto non-coated commercially available angioplasty balloons. The coating of the angioplasty balloons was evaluated for drug deposition and coating efficiency using high performance liquid chromatography tandem mass spectrometry. Drug transfer and retention of the coated angioplasty balloons into arterial segments were evaluated ex vivo using harvested pig arteries in a pulsatile flow bioreactor. The air sprayer method successfully delivered varying excipients including bovine serum albumin (BSA), urea and iohexol. The air spray method was configured to coat four angioplasty balloons simultaneously with paclitaxel and iohexol with an average paclitaxel load of 4.0 ± 0.70 µg/mm2. The intra-day (wi...Continue Reading

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Citations

Jan 23, 2020·Journal of Biomedical Materials Research. Part B, Applied Biomaterials·Kirby FuglsbySujan Lamichhane
Apr 5, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·Emily GoelSaami K Yazdani
Sep 28, 2020·International Journal of Cardiology·D VenetsanosJ Alfredsson
Dec 3, 2020·Pharmaceuticals·Claire V CawthonSaami K Yazdani
Oct 15, 2020·Molecules : a Journal of Synthetic Chemistry and Natural Product Chemistry·I RykowskaR Nowak

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