Coating Matters: Review on Colloidal Stability of Nanoparticles with Biocompatible Coatings in Biological Media, Living Cells and Organisms

Current Medicinal Chemistry
Jonas Schubert, Munish Chanana

Abstract

Within the last two decades, the field of nanomedicine has not developed as successfully as has widely been hoped for. The main reason for this is the immense complexity of the biological systems, including the physico-chemical properties of the biological fluids as well as the biochemistry and the physiology of living systems. The nanoparticles' physicochemical properties are also highly important. These differ profoundly from those of freshly synthesized particles when applied in biological/living systems as recent research in this field reveals. The physico-chemical properties of nanoparticles are predefined by their structural and functional design (core and coating material) and are highly affected by their interaction with the environment (temperature, pH, salt, proteins, cells). Since the coating material is the first part of the particle to come in contact with the environment, it does not only provide biocompatibility, but also defines the behavior (e.g. colloidal stability) and the fate (degradation, excretion, accumulation) of nanoparticles in the living systems. Hence, the coating matters, particularly for a nanoparticle system for biomedical applications, which has to fulfill its task in the complex environment of ...Continue Reading

Citations

Sep 26, 2020·Beilstein Journal of Nanotechnology·Konstantin PaliienkoTatiana Borisova
Jan 6, 2021·International Journal of Molecular Sciences·Wided Najahi-MissaouiBrian S Cummings
Jan 16, 2021·Chemical Reviews·Mukaddes IzciStefaan J Soenen
Nov 8, 2020·Materials·Anna FlorczakHanna Dams-Kozlowska
Apr 27, 2021·Bioactive Materials·Damla KeskinPatrick van Rijn
May 7, 2021·Journal of Photochemistry and Photobiology. B, Biology·Mohammad AshfaqR V Mangalaraja
Jun 8, 2021·Advances in Colloid and Interface Science·Małgorzata JurakKlaudia Szafran
Jul 3, 2021·Polymers·Daniela J Hernández-CastilloMayra A Alvarez Lemus
Jul 3, 2021·Materials·Hernán CortésGerardo Leyva-Gómez
Jul 25, 2021·International Journal of Molecular Sciences·Fabio VianelloMassimiliano Magro
Oct 1, 2021·Journal of Materials Chemistry. B, Materials for Biology and Medicine·Pyeong Seok ChoiJeong Hoon Park

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Methods Mentioned

BETA
dynamic light scattering
transfection
acetylation

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