PMID: 9429094Jan 16, 1998Paper

Coating PTFE vascular prostheses with a fibroblastic matrix improves cell retention when subjected to blood flow

Journal of Biomedical Materials Research
J BujánJ San-Román

Abstract

An investigation was made into the effect of blood flow on endothelial cells (EC) and mesothelial cells (MC) seeded on a vascular expanded polytetrafluoroethylene (ePTFE) prosthesis coated with a fibroblastic matrix. Endothelial cells were obtained from the external jugular vein and MC from the omentum. To test the performance of prostheses, a custom designed, femoral "ex vivo" circuit was developed in mongrel dogs. Four study groups were established: a control group, A1, where prostheses were uncoated and seeded with EC; a second control group, A2, where prostheses were uncoated and seeded with MC; group B1 where prostheses were coated with a fibroblastic matrix and seeded with EC; and group B2 where coated prostheses were seeded with MC. All cells were labeled with 111Indium oxine (10 microCi/mL) before seeding. After the seeded cells had formed a monolayer on the ePTFE prostheses (which took approximately 24 h) the prostheses were placed in the "ex vivo" circuit. The rates of blood flow to which prostheses were exposed were measured at the point of inflow (117.5 +/- 12.50 mL/min, mean +/- SD) and outflow (72.6 +/- 14.3 mL/min). MC showed a greater baseline radionuclide uptake than did EC. The cells of groups B1 and B2 adhere...Continue Reading

References

Jul 1, 1991·The British Journal of Surgery·J S BuddP R Bell
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Citations

Jan 24, 2002·Medical & Biological Engineering & Computing·H J SalacinskiA M Seifalian
Feb 12, 2004·Journal of Biomaterials Science. Polymer Edition·Shrojal DesaiR P Singh
Sep 4, 1999·Endothelium : Journal of Endothelial Cell Research·L BordenaveD Midy
Feb 26, 2004·Journal of Vascular Surgery·Murielle Rémy-ZolghadriFrançois A Auger
Dec 17, 2003·Journal of Biomedical Materials Research. Part a·Sharon SagnellaKandice Kottke-Marchant
Sep 7, 2001·Journal of Geophysical Research·D VanimanS Chipera

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