Cobalt-Catalyzed α-Arylation of Substituted α-Halogeno β-Lactams

Organic Letters
Vanessa KochJanine Cossy

Abstract

The treatment of 3-bromo β-lactams by an aryl Grignard, in the presence of CoCl2 (2 mol %) and TMEDA (2 mol %) in THF, produces 3-aryl β-lactams in good yields and excellent diastereoselectivity.

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