Cobalt-Catalyzed Acceptorless Dehydrogenative Coupling of Primary Alcohols to Esters

Organic Letters
Keshav PaudelKeying Ding

Abstract

A novel catalytic system with a tripodal cobalt complex is developed for efficiently converting primary alcohols to esters. KO tBu is found essential to the transformation. A preliminary mechanistic study suggests a plausible reaction route that involves an initial Co-catalyzed dehydrogenation of alcohol to aldehyde, followed by a Tishchenko-type pathway to ester mediated by KO tBu.

References

Aug 4, 2005·Journal of the American Chemical Society·Jing ZhangDavid Milstein
Apr 27, 2011·Dalton Transactions : an International Journal of Inorganic Chemistry·Marcello BertoliBrandon Moore
Feb 10, 2012·Angewandte Chemie·Denis SpasyukDmitry G Gusev
May 30, 2013·Journal of the American Chemical Society·Guoqi ZhangSusan K Hanson
Oct 17, 2015·Angewandte Chemie·Sina RöslerRhett Kempe
Apr 12, 2017·The Journal of Organic Chemistry·Keying DingJessie Weatherly

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