Cobalt-Catalyzed Aerobic Cross-Dehydrogenative Coupling of C-H and Thiols in Water for C-S Formation

The Journal of Organic Chemistry
Xin HuangGuanyu Yang

Abstract

Organosulfides have great significance and value in synthetic and biological chemistry. To establish a versatile and green methodology for C-S bond generation, we successfully developed a new aerobic cross-dehydrogenative coupling of C-H and S-H to synthesize aryl sulfides in water, utilizing CoPcS as the catalyst and O2 as the oxidant. This protocol shows great tolerance of a wide range of substrates. A large variety of organosulfur compounds were produced in modest to excellent yields.

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Citations

May 19, 2020·Organic & Biomolecular Chemistry·Jianxiao LiHuanfeng Jiang
Oct 12, 2018·Topics in Current Chemistry·Akram HosseinianEsmail Vessally
Jan 17, 2019·Organic & Biomolecular Chemistry·Shanyu TangBingxin Yuan
May 11, 2018·Topics in Current Chemistry·Richard S Glass
Mar 31, 2021·The Journal of Organic Chemistry·Amy C Dodds, Andrew Sutherland
Jul 13, 2021·The Journal of Organic Chemistry·Dong-Yang HanDa-Zhen Xu
Aug 4, 2020·ACS Omega·Yueting WeiYanlong Gu
Sep 20, 2019·The Journal of Organic Chemistry·Poonam Sharma, Nidhi Jain
Jul 22, 2018·The Journal of Organic Chemistry·David K RomneyChao-Jun Li
Dec 22, 2020·The Journal of Organic Chemistry·Wenqi ZhaoGuo-Jun Deng

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