Cobalt-Catalyzed Oxidative Annulation of Nitrogen-Containing Arenes with Alkynes: An Atom-Economical Route to Heterocyclic Quaternary Ammonium Salts

Angewandte Chemie
Sekar PrakashChien-Hong Cheng

Abstract

Four cobalt-catalyzed oxidative annulation reactions of nitrogen-containing arenes with alkynes proceeds by C-H activation, thus leading to biologically useful quaternary ammonium salts, including pyridoisoquinolinium, cinnolinium, isoquinolinium, and quinolizinium salts, in high yields. The results are comparable to those reactions catalyzed by rhodium and ruthenium complexes. The transformation of the salts into various N-heterocycles has also been demonstrated.

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Citations

Jun 25, 2016·The Journal of Organic Chemistry·Hui LiuJun Wang
Nov 5, 2016·The Journal of Organic Chemistry·David SucunzaJuan J Vaquero
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