Cobalt chloride-mediated protein kinase Cα (PKCα) phosphorylation induces hypoxia-inducible factor 1α (HIF1α) in the nucleus of gastric cancer cell

Biochemical and Biophysical Research Communications
Suvasmita RathAsima Bhattacharyya

Abstract

Hypoxia promotes cancer progression, and metastasis. The major protein expressed in hypoxic solid cancer is hypoxia-inducible factor 1 (HIF1). We show that enhanced phosphorylation of a conventional protein kinase C isoform, PKCα, at threonine 638 (T(638)) by hypoxia-mimetic cobalt chloride induces HIF1α in nuclei of gastric epithelial cells (GECs). Moreover, phospho-T(638)-PKCα (P-PKCα) interacts with p300-HIF1α complex in the nuclei of hypoxic GECs and PKCα phosphorylation at T(638) enhances transcriptional activity of HIF1α. High P-PKCα expression in neoplastic gastric cancer biopsy samples as compared to nonneoplastic samples suggests that P-PKCα might act as an indicator of gastric cancer progression.

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Citations

Nov 29, 2016·The International Journal of Biochemistry & Cell Biology·Suvasmita RathAsima Bhattacharyya
Jan 22, 2020·Biochemical and Biophysical Research Communications·Aditi NayakAnasuya Roychowdhury
Nov 30, 2018·Chemical Reviews·Bernhard EnglingerWalter Berger

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