Cobalt-Directed Assembly of Antibodies onto Metal-Phenolic Networks for Enhanced Particle Targeting.

Nano Letters
Wenjie ZhangFrank Caruso

Abstract

The orientation-specific immobilization of antibodies onto nanoparticles, to preserve antibody-antigen recognition, is a key challenge in developing targeted nanomedicines. Herein, we report the targeting ability of metal-phenolic network (MPN)-coated gold nanoparticles with surface-physisorbed antibodies against respective antigens. The MPN coatings were self-assembled from metal ions (FeIII, CoII, CuII, NiII, or ZnII) cross-linked with tannic acid. Upon physisorption of antibodies, all particle systems exhibited enhanced association with target antigens, with CoII systems demonstrating more than 2-fold greater association. These systems contained more metal atoms distributed in a way to specifically interact with antibodies, which were investigated by molecular dynamics simulations. A model antibody fragment crystallizable (Fc) region in solution with CoII-tannic acid complexes revealed that the solvent-exposed CoII can directly coordinate to the histidine-rich portion of the Fc region. This one-pot interaction suggests anchoring of the antibody Fc region to the MPN on nanoparticles, allowing for enhanced targeting.

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Citations

Feb 18, 2021·Chemical Society Reviews·Di WuJesse V Jokerst
Feb 27, 2021·ACS Applied Materials & Interfaces·Salvio Suárez-GarcíaFernando Novio
Mar 7, 2021·Journal of Controlled Release : Official Journal of the Controlled Release Society·Tommaso Casalini
Mar 11, 2021·Biomaterials Science·Peng LiuWenhu Zhou
Jun 25, 2021·Nature Communications·Z L ShawSumeet Walia
Aug 19, 2021·Journal of Chemical Information and Modeling·Sachini P Kadaoluwa PathirannahalageAndrew J Christofferson

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