Cobalt exposure and lung disease in tungsten carbide production. A cross-sectional study of current workers

The American Review of Respiratory Disease
N L SprinceR I Chamberlin

Abstract

A cross-sectional study of 1,039 tungsten carbide (TC) production workers was carried out. The purposes were (1) to evaluate the prevalence of interstitial lung disease (ILD) and work-related wheezing, (2) to assess correlations between cobalt exposure and pulmonary disease, (3) to compare lung disease in grinders of hard carbide versus nongrinders, and (4) to evaluate the effects of new and previous threshold limit values for cobalt of 50 and 100 micrograms/m3. We obtained medical and occupational histories, flow-volume loops, single breath carbon monoxide diffusing capacity (DLCO), and chest radiographs. Time-weighted average cobalt levels were determined at every step in the production process. Work-related wheeze occurred in 113 participants (10.9%). Profusion greater than or equal to 1/0 occurred in 26 (2.6%) and interstitial lung disease (defined as profusion greater than or equal to 1M, FVC or DLCO less than or equal to 70%, and FEV1/FVC% greater than or equal to 75) in 7 (0.7%). The relative odds of work-related wheeze was 2.1 times for present cobalt exposures exceeding 50 micrograms/m3 compared with exposures less than or equal to 50 micrograms/m3. The relative odds of profusion greater than or equal to 1/0 was 5.1 ti...Continue Reading

References

Jan 1, 1975·American Industrial Hygiene Association Journal·E J KerfootE Domeier
Nov 1, 1971·Annals of Internal Medicine·E O Coates, J H Watson
Oct 1, 1984·Chest·N L SprinceH Kazemi
Sep 1, 1980·Thorax·I SjögrenO Zetterström

❮ Previous
Next ❯

Citations

Jan 1, 1992·American Journal of Industrial Medicine·S FigueroaW Beckett
Feb 1, 1993·American Journal of Industrial Medicine·J J MoulinM Mercier-Gallay
Nov 1, 1994·American Journal of Industrial Medicine·G LasfarguesJ Moline
Jan 1, 1990·International Archives of Occupational and Environmental Health·J P Gennart, R Lauwerys
Jun 30, 1994·The Science of the Total Environment·R Lauwerys, D Lison
Jun 30, 1994·The Science of the Total Environment·G Chiappino
Jun 30, 1994·The Science of the Total Environment·G MosconiP C Parigi
Jun 30, 1994·The Science of the Total Environment·I FranchiniE Bergamaschi
Jun 30, 1994·The Science of the Total Environment·G MichettiL Michetti
Jun 30, 1994·The Science of the Total Environment·R SuardiS Piazzolla
Jun 30, 1994·The Science of the Total Environment·A MarianoA Innocenti
Jul 17, 2008·Journal of Exposure Science & Environmental Epidemiology·Aleksandr B StefaniakGregory A Day
Sep 18, 1999·Respirology : Official Journal of the Asian Pacific Society of Respirology·M KinoshitaK Oizumi
Jan 1, 1992·British Journal of Industrial Medicine·A FischbeinA Miller
Dec 1, 1992·British Journal of Industrial Medicine·J H AuchinclossD J Peppi
Mar 1, 1995·Occupational and Environmental Medicine·S M KennedyK Teschke
Mar 1, 1996·Occupational and Environmental Medicine·Y KusakaS Goto
Mar 1, 1996·Occupational and Environmental Medicine·Y KusakaS Goto
Sep 28, 2012·Journal of Occupational Medicine and Toxicology·Xaver BaurHenning Vellguth
Aug 10, 2000·Environmental Health Perspectives·P KelleherL S Newman
May 22, 2008·Journal of Occupational Health·Yutaka HosodaSumiko Sasagawa
Dec 24, 2004·AJR. American Journal of Roentgenology·Jin Wook ChoiJai Soung Park
Jun 26, 1999·Journal of Toxicology. Clinical Toxicology·D G Barceloux
Jan 24, 2008·Industrial Health·Aleksandr B StefaniakWilliam P Chisholm
Dec 8, 2009·Archivos de bronconeumología·M Angeles MonteroFerràn Morell
Sep 22, 2007·Seminars in Diagnostic Pathology·Chih-wei Wang, Thomas V Colby
Dec 3, 2015·Lung India : Official Organ of Indian Chest Society·Kapil IyerJyotsna M Joshi
Jun 22, 1999·Toxicology and Applied Pharmacology·A RengasamyJ S Fedan
Aug 4, 2001·Toxicology and Applied Pharmacology·J S Fedan, D Cutler
Nov 12, 2009·Journal of Occupational and Environmental Hygiene·Aleksandr B StefaniakStephen S Leonard
Oct 19, 2017·Inhalation Toxicology·Lewis J WilliamsGraeme R Zosky
Dec 25, 2009·Advances in Anatomic Pathology·R Nagarjun RaoSaul Suster

❮ Previous
Next ❯

Related Concepts

Trending Feeds

COVID-19

Coronaviruses encompass a large family of viruses that cause the common cold as well as more serious diseases, such as the ongoing outbreak of coronavirus disease 2019 (COVID-19; formally known as 2019-nCoV). Coronaviruses can spread from animals to humans; symptoms include fever, cough, shortness of breath, and breathing difficulties; in more severe cases, infection can lead to death. This feed covers recent research on COVID-19.

Blastomycosis

Blastomycosis fungal infections spread through inhaling Blastomyces dermatitidis spores. Discover the latest research on blastomycosis fungal infections here.

Nuclear Pore Complex in ALS/FTD

Alterations in nucleocytoplasmic transport, controlled by the nuclear pore complex, may be involved in the pathomechanism underlying multiple neurodegenerative diseases including Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Here is the latest research on the nuclear pore complex in ALS and FTD.

Applications of Molecular Barcoding

The concept of molecular barcoding is that each original DNA or RNA molecule is attached to a unique sequence barcode. Sequence reads having different barcodes represent different original molecules, while sequence reads having the same barcode are results of PCR duplication from one original molecule. Discover the latest research on molecular barcoding here.

Chronic Fatigue Syndrome

Chronic fatigue syndrome is a disease characterized by unexplained disabling fatigue; the pathology of which is incompletely understood. Discover the latest research on chronic fatigue syndrome here.

Evolution of Pluripotency

Pluripotency refers to the ability of a cell to develop into three primary germ cell layers of the embryo. This feed focuses on the mechanisms that underlie the evolution of pluripotency. Here is the latest research.

Position Effect Variegation

Position Effect Variagation occurs when a gene is inactivated due to its positioning near heterochromatic regions within a chromosome. Discover the latest research on Position Effect Variagation here.

STING Receptor Agonists

Stimulator of IFN genes (STING) are a group of transmembrane proteins that are involved in the induction of type I interferon that is important in the innate immune response. The stimulation of STING has been an active area of research in the treatment of cancer and infectious diseases. Here is the latest research on STING receptor agonists.

Microbicide

Microbicides are products that can be applied to vaginal or rectal mucosal surfaces with the goal of preventing, or at least significantly reducing, the transmission of sexually transmitted infections. Here is the latest research on microbicides.