Cobalt-protoporphyrin suppresses expression of genetic obesity in homozygous (fa/fa) Zucker rats

Pharmacology
R A Galbraith, A Kappas

Abstract

Profound obesity is conferred on the Zucker rat by homozygosity for a recessive gene (fa/fa); the heterozygous animal is lean. Subcutaneous administration of the heme analogue cobalt-protoporphyrin produces a long-sustained reduction in body weight of the homozygous Zucker rat. Intracerebroventricular injection of the compound, in a single small dose, results in an extremely prolonged (approximately 300 days) lowering of the 'set point' for body weight regulation, confirming a central nervous system action of the metalloporphyrin. The effect of cobalt-protoporphyrin is so pronounced that the phenotype of the homozygous, obese Zucker rat is changed to that of its lean littermate.

Citations

May 30, 1998·Xenobiotica; the Fate of Foreign Compounds in Biological Systems·M R FengW McNally
Feb 8, 2005·Stereotactic and Functional Neurosurgery·David A VincentEdward R Laws Jr
Oct 27, 2006·FASEB Journal : Official Publication of the Federation of American Societies for Experimental Biology·Ying ShanHerbert L Bonkovsky
May 30, 2014·The Journal of Biological Chemistry·Edna Matta-CamachoDouglas J Kojetin

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